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腺样体切除术治疗儿童复发性或慢性鼻部症状。

Adenoidectomy for recurrent or chronic nasal symptoms in children.

作者信息

van den Aardweg Maaike Ta, Schilder Anne Gm, Herkert Ellen, Boonacker Chantal Wb, Rovers Maroeska M

机构信息

Department of Otorhinolaryngology, University Medical Center Utrecht, Wilhelmina Children's Hospital, HP: KE.04.140.5, PO Box 85090, Utrecht, Netherlands, 3508 AB.

出版信息

Cochrane Database Syst Rev. 2010 Jan 20;2010(1):CD008282. doi: 10.1002/14651858.CD008282.

Abstract

BACKGROUND

Adenoidectomy, surgical removal of the adenoids, is a common ENT operation worldwide in children with recurrent or chronic nasal symptoms. A systematic review on the effectiveness of adenoidectomy in this specific group has not previously been performed.

OBJECTIVES

To assess the effectiveness of adenoidectomy versus non-surgical management in children with recurrent or chronic nasal symptoms.

SEARCH STRATEGY

We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; CINAHL; Web of Science; BIOSIS Previews; Cambridge Scientific Abstracts; mRCT and additional sources for published and unpublished trials. The date of the most recent search was 30 March 2009.

SELECTION CRITERIA

Randomised controlled trials comparing adenoidectomy, with or without tympanostomy tubes, versus non-surgical management or tympanostomy tubes alone in children with recurrent or chronic nasal symptoms. The primary outcome studied was the number of episodes, days per episode and per year with nasal symptoms and the proportion of children with recurrent episodes of nasal symptoms. Secondary outcomes were mean number of episodes, mean number of days per episode and per year, and proportion of children with nasal obstruction alone.

DATA COLLECTION AND ANALYSIS

Two authors assessed trial quality and extracted data independently.

MAIN RESULTS

Only one study included children scheduled for adenoidectomy because of recurrent or chronic nasal symptoms or middle ear disease. In this study no beneficial effect of adenoidectomy was found. The numbers in this study were, however, small (n = 76) and the quality of the study was moderate. The outcome was improvement in episodes of common colds. The risk differences were non-significant, being 2% (95% CI -18% to 22%) and -11% (95% CI -28% to 7%) after 12 and 24 months, respectively.A second study included children with recurrent acute otitis media (n = 180). As otitis media is known to be associated with nasal symptoms, the number of days with rhinitis was studied as a secondary outcome measure. The risk difference was non-significant, being -4 days (95% CI -13 to 7 days).

AUTHORS' CONCLUSIONS: Current evidence regarding the effect of adenoidectomy on recurrent or chronic nasal symptoms or nasal obstruction alone is sparse, inconclusive and has a significant risk of bias.High quality trials assessing the effectiveness of adenoidectomy in children with recurrent or chronic nasal symptoms should be initiated.

摘要

背景

腺样体切除术,即手术切除腺样体,是全球范围内针对有反复或慢性鼻部症状儿童的常见耳鼻喉科手术。此前尚未对腺样体切除术在这一特定群体中的有效性进行系统评价。

目的

评估腺样体切除术与非手术治疗对有反复或慢性鼻部症状儿童的有效性。

检索策略

我们检索了Cochrane耳鼻喉疾病组试验注册库;Cochrane对照试验中央注册库(CENTRAL);PubMed;EMBASE;CINAHL;科学引文索引;BIOSIS预评文摘;剑桥科学文摘;mRCT以及其他已发表和未发表试验的来源。最近一次检索日期为2009年3月30日。

选择标准

比较腺样体切除术(伴或不伴鼓膜置管)与非手术治疗或仅鼓膜置管对有反复或慢性鼻部症状儿童疗效的随机对照试验。所研究的主要结局为鼻部症状发作次数、每次发作天数和每年发作天数以及有反复鼻部症状发作儿童的比例。次要结局为发作平均次数、每次发作和每年的平均天数以及仅有鼻塞儿童的比例。

数据收集与分析

两位作者独立评估试验质量并提取数据。

主要结果

仅有一项研究纳入了因反复或慢性鼻部症状或中耳疾病而计划行腺样体切除术的儿童。在这项研究中未发现腺样体切除术有有益效果。然而,该研究中的样本量较小(n = 76)且研究质量中等。结局指标为普通感冒发作情况的改善。风险差异无统计学意义,12个月和24个月后的风险差异分别为2%(95%可信区间 -18%至22%)和 -11%(95%可信区间 -28%至7%)。第二项研究纳入了有反复急性中耳炎的儿童(n = 180)。由于已知中耳炎与鼻部症状相关,因此将鼻炎天数作为次要结局指标进行研究。风险差异无统计学意义,为 -4天(95%可信区间 -13至7天)。

作者结论

目前关于腺样体切除术对反复或慢性鼻部症状或仅鼻塞的影响的证据稀少、尚无定论且存在显著的偏倚风险。应开展高质量试验以评估腺样体切除术对有反复或慢性鼻部症状儿童的有效性。

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