Rasmuson T, Björk G R, Hietala S O, Stenling R, Ljungberg B
Department of Oncology, University Hospital, Umeå, Sweden.
Acta Oncol. 1991;30(1):11-5. doi: 10.3109/02841869109091806.
Pseudouridine is the most prevalent modified nucleoside excreted in urine, mainly as a degradation product of t-RNA. The level of pseudouridine excretion was analyzed in 71 patients with renal cell carcinoma prior to treatment. An increased excretion was demonstrated in 27 of 48 patients (56%) in stage II-IV, compared to 2 of 23 patients (9%) in stage I. Survival time was significantly reduced in patients with increased excretion. The level of pseudouridine correlated to tumor grade and tumor size. Using Cox's proportional hazard model, only clinical stage and level of pseudouridine excretion were independent predictors of prognosis.
假尿苷是尿液中排出的最常见的修饰核苷，主要作为t-RNA的降解产物。在71例肾细胞癌患者治疗前分析了假尿苷的排泄水平。II-IV期48例患者中有27例（56%）排泄增加，而I期23例患者中有2例（9%）排泄增加。排泄增加的患者生存时间显著缩短。假尿苷水平与肿瘤分级和肿瘤大小相关。使用Cox比例风险模型，只有临床分期和假尿苷排泄水平是预后的独立预测因素。
