Clemmensen O J, Kieffer M, Sjølin K E
Department of Pathology, Sundby Hospital, Copenhagen, Denmark.
Acta Derm Venereol. 1987;67(4):310-4.
The excretion of pseudouridine in the urine of 17 patients with psoriasis was significantly increased. The largest increase was found in patients with psoriatic arthritis. No correlation between the extent of psoriasis and pseudouridine excretion was found. The excretion of pseudouridine was followed in 10 of the 17 patients during treatment with anthralin or PUVA. Pseudouridine excretion decreased significantly during therapy. The possible application of pseudouridine excretion in monitoring the disease activity in psoriasis is discussed.
17例银屑病患者尿液中假尿苷的排泄量显著增加。在银屑病关节炎患者中发现增加幅度最大。未发现银屑病严重程度与假尿苷排泄之间存在相关性。在17例患者中的10例接受蒽林或补骨脂素紫外线A光化学疗法（PUVA）治疗期间，对其假尿苷排泄情况进行了跟踪监测。治疗期间假尿苷排泄量显著下降。本文讨论了假尿苷排泄在监测银屑病疾病活动中的可能应用。
