毛萼丁公藤中的罕见双香豆素及一种绿原酸衍生物。

Rare biscoumarins and a chlorogenic acid derivative from Erycibe obtusifolia.

作者信息

Liu Jian, Feng Ziming, Xu Jianfu, Wang Yinghong, Zhang Peicheng

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China.

出版信息

Phytochemistry. 2007 Jul;68(13):1775-80. doi: 10.1016/j.phytochem.2007.05.001. Epub 2007 Jun 13.

DOI:10.1016/j.phytochem.2007.05.001

PMID:17570448

Abstract

Three coumarins, 7,7'-dihydroxy-6,6'-dimethoxy-3,3'-biscoumarin (1), 7,7'-dihydroxy-6,6'-dimethoxy-8,8'-biscoumarin (2) and 7-O-[4'-O-(3'',4''-dihydroxycinnamyl)-beta-d-glucopyranosyl]-6-methoxycoumarin (3), and a chlorogenic acid derivative, methyl-3-O-(4''-hydroxy-3'',5''-dimethoxybenzoyl)-chlorogenate (4) were isolated from the roots of Erycibe obtusifolia along with four known coumarins, scopoletin (5), scopolin (6), cleomiscosin A (7) and cleomiscosin B (8). Their structures were elucidated by spectroscopic methods. Among them, compounds (1) and (2) are rare carbon-carbon linked symmetrical biscoumarins.

摘要

从钝叶丁公藤根部分离得到3种香豆素，7,7'-二羟基-6,6'-二甲氧基-3,3'-联香豆素（1）、7,7'-二羟基-6,6'-二甲氧基-8,8'-联香豆素（2）和7-O-[4'-O-(3'',4''-二羟基肉桂酰基)-β-D-吡喃葡萄糖基]-6-甲氧基香豆素（3），以及1种绿原酸衍生物，3-O-(4''-羟基-3'',5''-二甲氧基苯甲酰基)-绿原酸甲酯（4），同时还得到4种已知香豆素，东莨菪素（5）、东莨菪苷（6）、臭矢菜素A（7）和臭矢菜素B（8）。通过光谱方法确定了它们的结构。其中，化合物（1）和（2）是罕见的碳-碳连接对称双香豆素。