Nagamoto H T, Adler L E, Waldo M C, Griffith J, Freedman R
Denver Veterans Administration Medical Center, CO.
Schizophr Res. 1991 Jan-Feb;4(1):31-40. doi: 10.1016/0920-9964(91)90007-e.
Auditory evoked potentials were recorded using a paired stimulus, conditioning-testing paradigm from 14 schizophrenic patients and 13 normal subjects with no family history of psychotic disorder. Previous studies of the vertex P50 wave using this paradigm have demonstrated a possible sensory gating deficit in schizophrenics, as shown by their failure to diminish the response to a test stimulus presented 500 ms after a conditioning stimulus. Recordings were made at Cz, Fz, C3, T3, C4, and T4, to compare effects at different recording sites with this paradigm. Schizophrenics had significantly poorer sensory gating than normals, with the most significant difference between the groups at Cz. In addition to the 500 ms interval, subjects were also recorded at a conditioning-testing interval of 100 ms. Most schizophrenics showed normal sensory gating at the 100 ms interval, despite their abnormalities at 500 ms. The results indicate that Cz is optimal recording site for this paradigm, and that gating abnormalities in schizophrenic subjects are limited to specific interstimulus intervals.
采用配对刺激、条件-测试范式，对14名精神分裂症患者和13名无精神障碍家族史的正常受试者记录听觉诱发电位。以往使用该范式对头顶P50波的研究表明，精神分裂症患者可能存在感觉门控缺陷，表现为在条件刺激后500毫秒呈现测试刺激时，他们对测试刺激的反应未能减弱。在Cz、Fz、C3、T3、C4和T4进行记录，以比较该范式在不同记录部位的效果。精神分裂症患者的感觉门控明显比正常人差，两组之间在Cz处差异最为显著。除了500毫秒的间隔外，还在100毫秒的条件-测试间隔对受试者进行记录。大多数精神分裂症患者在100毫秒间隔时表现出正常的感觉门控，尽管他们在500毫秒时存在异常。结果表明，Cz是该范式的最佳记录部位，且精神分裂症患者的门控异常仅限于特定的刺激间隔。
