Fukuda M, Niwa S, Hiramatsu K, Hata A, Saitoh O, Hayashida S, Nakagome K, Iwanami A, Sasaki T, Honda H, Itoh K
Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan.
Schizophr Res. 1997 Jun 20;25(3):231-42. doi: 10.1016/s0920-9964(97)00028-5.
In order to clarify the remediability of behavioral and electrophysiological abnormalities in schizophrenia, hit rate, reaction time, and P3 amplitude from auditory event-related potentials were evaluated before and after feedback training of a task in 14 schizophrenics and 12 age-matched normal controls. Although mean changes in the three indices due to the training were nonsignificant in both schizophrenic and normal control groups as a whole, the changes in hit rate and reaction time correlated significantly with the P3 amplitude change in the schizophrenic (r = 0.60 and -0.58, respectively) but not in the normal control group. The P3 amplitude change also correlated with the P3 amplitude before the training only in the schizophrenic group (r = -0.68), suggesting that the training was more effective for the schizophrenic patients with marked P3 amplitude reduction. The observed P3 amplitude increase due to training may represent an electrophysiological correlate of a remediable aspect of behavioral deficits in schizophrenics, which may underlie the effectiveness of nonpharmacological treatments.
为了阐明精神分裂症患者行为和电生理异常的可矫正性，对14名精神分裂症患者和12名年龄匹配的正常对照者在一项任务的反馈训练前后，评估了听觉事件相关电位的命中率、反应时间和P3波幅。尽管总体上训练导致的这三项指标的平均变化在精神分裂症组和正常对照组中均无统计学意义，但命中率和反应时间的变化与精神分裂症患者的P3波幅变化显著相关（分别为r = 0.60和 -0.58），而在正常对照组中则无此关联。P3波幅变化也仅在精神分裂症组中与训练前的P3波幅相关（r = -0.68），这表明训练对P3波幅明显降低的精神分裂症患者更有效。观察到的训练导致的P3波幅增加可能代表了精神分裂症患者行为缺陷中可矫正方面的电生理关联，这可能是非药物治疗有效性的基础。
