Gonsalvez C J, Gordon E, Anderson J, Pettigrew G, Barry R J, Rennie C, Meares R
Department of Psychology, Westmead Hospital, NSW, Australia.
Psychiatry Res. 1995 Sep 8;58(1):69-75. doi: 10.1016/0165-1781(95)02315-n.
This event-related potential study systematically varied the number of nontargets (1, 3, 5, 7, 9) preceding the target tone in an oddball experiment and examined the effect of this on N2, P3, and reaction time measures in schizophrenic patients and normal volunteers. Schizophrenic patients were found to have reduced P3 amplitudes, but this reduction was restricted to series when the targets followed an intermediate number (3-7) of nontargets, and not when targets followed a short (1) or long series (9) of nontargets. Although other interpretations of this finding are possible, the pattern of results could be explained by the hypothesis that the refractory period governing the generation of the P3 component was prolonged in schizophrenia.
在一项oddball实验中，这项与事件相关电位的研究系统地改变了目标音调之前非目标刺激的数量（1、3、5、7、9），并考察了这对精神分裂症患者和正常志愿者的N2、P3及反应时间测量值的影响。研究发现，精神分裂症患者的P3波幅降低，但这种降低仅限于目标刺激之前有中等数量（3 - 7个）非目标刺激的序列，而在目标刺激之前有少量（1个）或大量（9个）非目标刺激的序列中则未出现。尽管对这一发现可能有其他解释，但该结果模式可以用以下假设来解释：在精神分裂症中，控制P3成分产生的不应期延长。
