Second Department of Internal Medicine, Propaedeutic Oncology Section, University of Athens, Attikon University Hospital, Rimini 1, Haidari, Athens, Greece.
Cancer Treat Rev. 2010 May;36(3):262-7. doi: 10.1016/j.ctrv.2009.12.011. Epub 2010 Jan 25.
Cisplatin-based treatment has significantly increased survival in testicular cancer patients. Therefore, there has been enough interest for the late toxic effects of chemotherapy which affect the quality of life of the cancer survivors. These toxic effects may either persist or present long after the end of chemotherapy and involve the impairment of renal function, neurotoxicity, pulmonary toxicity and vascular disease. Also, a major issue experienced by a large number of patients is infertility, which has been improved due to modified surgical techniques, reduced treatment intensity, the use of sperm cryopreservation and methods of assisted reproduction. Physicians should also be aware of the risk of secondary malignancy development. Therefore, close follow-up of the testicular cancer survivors as well as, focus on minimizing treatment complications through improvement of treatment strategies are warranted.
顺铂为基础的治疗显著提高了睾丸癌患者的生存率。因此，人们对化疗的迟发性毒副作用产生了足够的兴趣，这些毒副作用会影响癌症幸存者的生活质量。这些毒副作用可能在化疗结束后很长时间内仍然存在或出现，包括肾功能损害、神经毒性、肺毒性和血管疾病。此外，大量患者面临的一个主要问题是不育症，由于改良的手术技术、降低治疗强度、精子冷冻保存和辅助生殖方法的应用，这一问题已有所改善。医生还应该意识到继发恶性肿瘤发展的风险。因此，有必要对睾丸癌幸存者进行密切随访，并通过改进治疗策略来关注减轻治疗并发症。
