Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, Rio de Janeiro, RJ, Brazil.
Pathol Res Pract. 2010 Mar 15;206(3):168-73. doi: 10.1016/j.prp.2009.11.004. Epub 2010 Jan 21.
We studied the effects of exercise training in treating renal impairment due to hypertension and obesity in rats. Diet-induced obese and non-obese Wistar rats were assigned to four groups: Sed-Ob, Ex-Ob, Sed-C, and Ex-C (motor treadmill for 13 weeks; Ex=exercise-trained, C=control, Ob=obese, Sed=sedentary). Creatinine, proteinuria, and kidney structure were evaluated. Sed-C rats had normal and stable blood pressure (BP), while Sed-Ob rats developed hypertension. After 4 weeks of exercise, BP decreased in exercise-trained groups (less than 25% at the end of the experiment in obese rats, and less than 10% in non-obese rats). Both the body mass and retroperitoneal fat mass were lower in the exercise-trained groups than in the sedentary ones. Serum creatinine was not different among the groups, but the urinary protein excretion was significantly higher in the Sed-Ob group than in the matched non-obese group. Compared to the non-obese animals the mean glomerular volume increased by 45% in Sed-Ob rats and by 30% in Ex-Ob rats. Obese animals also showed increased mesangial volume density compared to non-obese animals. The present findings allow us to conclude that the exercise training could be an auxiliary practice to attenuate renal alterations seen in diet-induced obesity.
我们研究了运动训练对高血压和肥胖引起的肾功能损害的治疗作用。饮食诱导肥胖和非肥胖 Wistar 大鼠被分为四组：Sed-Ob、Ex-Ob、Sed-C 和 Ex-C（运动跑步机训练 13 周；Ex=运动训练，C=对照，Ob=肥胖，Sed=久坐）。评估了肌酐、蛋白尿和肾脏结构。Sed-C 大鼠的血压正常且稳定，而 Sed-Ob 大鼠则出现高血压。运动 4 周后，运动训练组的血压下降（肥胖大鼠在实验结束时下降了 25%以下，非肥胖大鼠下降了 10%以下）。与久坐组相比，运动训练组的体重和腹膜后脂肪量均较低。血清肌酐在各组之间无差异，但 Sed-Ob 组的尿蛋白排泄量明显高于匹配的非肥胖组。与非肥胖动物相比，Sed-Ob 大鼠的平均肾小球体积增加了 45%，Ex-Ob 大鼠增加了 30%。肥胖动物的肾小球系膜体积密度也高于非肥胖动物。本研究结果表明，运动训练可能是减轻饮食诱导肥胖引起的肾脏改变的辅助措施。
