Departament of Physical Education, Federal University of Maranhão, São Luis, MA, Brazil; Clinical and Experimental Research Laboratory in Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Metabolism. 2013 Oct;62(10):1477-84. doi: 10.1016/j.metabol.2013.05.009. Epub 2013 Jun 19.
The purpose of this study was to evaluate the effect of resistance training (RT) on body composition, systolic and diastolic blood pressures (BP), and activity of muscle MMP-2 in the left ventricle of high-fat fed rats.
MATERIALS/METHODS: We have evaluated 32 male Wistar rats divided into four experimental groups (n=8/each) according to diet and exercise status: sedentary (SED; standard diet), sedentary obese (SED-OB; diet: 30% of fat), RT (RT; standard diet) and RT obese (RT-OB; diet: 30% of fat). After weaning (day 21), animals were subjected to the experimental diet according to their groups during 24 weeks. A 12-week strength-training period was used, during which the rats climbed a 1.1-m vertical ladder with weights attached to their tails. Sessions were performed three times/week (Mondays, Wednesdays and Fridays), with 4-9 climbs/session and 8-12 dynamic movements/climb.
RT induced higher muscle MMP-2 activity in the left ventricle in RT and RT-OB groups. Moreover, this study demonstrated that RT promoted lower body and fat masses, fat percentage, systolic and diastolic BPs and higher fat free mass in both trained groups.
RT increased muscle MMP-2 activity in the left ventricle, induced positive changes on body composition and lowered BPs in high-fat diet fed rats, suggesting that it may be a useful tool to prevent alterations induced by high-fat diet consumption.
本研究旨在评估抗阻训练（RT）对高脂肪喂养大鼠左心室体成分、收缩压和舒张压（BP）及肌肉基质金属蛋白酶-2（MMP-2）活性的影响。
材料/方法：我们评估了 32 只雄性 Wistar 大鼠，根据饮食和运动状况分为 4 个实验组（每组 8 只）：安静（SED；标准饮食）、安静肥胖（SED-OB；饮食：30%脂肪）、RT（RT；标准饮食）和 RT 肥胖（RT-OB；饮食：30%脂肪）。断奶后（第 21 天），动物根据其组别接受实验饮食 24 周。进行了 12 周的力量训练期，在此期间，大鼠会用尾巴上绑的重物爬上 1.1 米高的垂直梯子。每周进行 3 次训练（周一、周三和周五），每次 4-9 次攀爬，每次 8-12 次动态运动/攀爬。
RT 诱导了 RT 和 RT-OB 组左心室肌肉 MMP-2 活性增加。此外，本研究表明，RT 增加了瘦体重和去脂体重，降低了体脂率、收缩压和舒张压，在两个训练组中都产生了积极的变化。
RT 增加了左心室肌肉 MMP-2 活性，对高脂肪饮食喂养大鼠的体成分产生了积极的变化，并降低了血压，提示它可能是预防高脂肪饮食引起的改变的有用工具。
