Quan Stuart F, Griswold Michael E, Iber Conrad, Nieto F Javier, Rapoport David M, Redline Susan, Sanders Mark, Young Terry
Arizona Respiratory Center and Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Sleep. 2002 Dec;25(8):843-9.
To determine the short-term variability of indices of disturbed respiration and sleep during 2 nights of unattended nonlaboratory polysomnography conducted several months apart.
Participants were randomly selected using a block design with stratification on preliminary estimates of 2 criteria: respiratory disturbance index [RDI3% (apnea or hypopnea events associated with > or = 3% O2 desaturation): < 15/hour total sleep time, > or = 15/hour total sleep time] and sleep efficiency (SEff: < 85% and > or = 85%). The RDI and sleep data from initial and repeated polysomnography were compared.
NA.
A subset of 99 participants in the Sleep Heart Health Study who agreed to have a repeat polysomnogram within 4 months of their original study.
NA.
Acceptable repeat polysomnograms were obtained in 91 subjects (mean study interval: 77 +/- 18 [sd] days; range: 31-112 days). There was no significant bias in RDI between study nights using several different RDI definitions including RDI3% and RDI4% (apnea or hypopnea events associated with > or = 4% O2 desaturation). Variability between studies estimated using intraclass correlations (ICC) ranged from 0.77 to 0.81. For subjects with a RDI3% < 15, variability increased as a function of increasing RDI, but for those with a RDI3% > or = 15, variability was constant. Body mass index, SEff, gender, or age did not directly predict RDI variability. Using RDI4% cutpoints of < or = 5, < or = 10 and < or = 15 events per hour of sleep demonstrated that 79.1%, 85.7%, and 87.9% of subjects, respectively, had the same classification of SDB status on both nights of study. There also was no significant bias in sleep staging, sleep efficiency, or arousal index between studies. However, variability was greater with ICC values ranging from 0.37 (% time in REM) to 0.76 (arousal index).
In the Sleep Heart Health Study, accurate estimates of the severity of sleep-disordered breathing and the quality of sleep were obtained from a single night of unattended nonlaboratory polysomnography. These findings may be applicable to other large epidemiologic studies provided that similar recording techniques and quality-assurance procedures are followed.
确定在相隔数月进行的两晚无人值守非实验室多导睡眠图检查期间，呼吸紊乱和睡眠指标的短期变异性。
采用区组设计并根据两个标准的初步估计进行分层随机选择参与者：呼吸紊乱指数[RDI3%（与≥3%氧饱和度下降相关的呼吸暂停或低通气事件）：总睡眠时间<15次/小时，≥15次/小时]和睡眠效率（SEff：<85%和≥85%）。比较初次和重复多导睡眠图检查的RDI和睡眠数据。
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睡眠心脏健康研究中的99名参与者子集，他们同意在原始研究的4个月内进行重复多导睡眠图检查。
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91名受试者获得了可接受的重复多导睡眠图（平均研究间隔：77±18[标准差]天；范围：31 - 112天）。使用包括RDI3%和RDI4%（与≥4%氧饱和度下降相关的呼吸暂停或低通气事件）在内的几种不同RDI定义，研究夜间之间的RDI无显著偏差。使用组内相关系数（ICC）估计的研究间变异性范围为0.77至0.81。对于RDI3%<15的受试者，变异性随RDI增加而增加，但对于RDI3%≥15的受试者，变异性保持恒定。体重指数、SEff、性别或年龄不能直接预测RDI变异性。使用每小时睡眠中RDI4%切点≤5、≤10和≤15次事件表明，分别有79.1%、85.7%和87.9%的受试者在两晚研究中阻塞性睡眠呼吸暂停（SDB）状态分类相同。研究之间在睡眠分期、睡眠效率或觉醒指数方面也无显著偏差。然而，变异性更大，ICC值范围从0.37（快速眼动睡眠中的时间百分比）到0.76（觉醒指数）。
在睡眠心脏健康研究中，通过一晚无人值守非实验室多导睡眠图检查可获得睡眠呼吸紊乱严重程度和睡眠质量的准确估计。如果遵循类似的记录技术和质量保证程序，这些发现可能适用于其他大型流行病学研究。
