Division of Nephrology, University of Florida, Gainesville, Fla., USA.
Blood Purif. 2010;29(2):158-62. doi: 10.1159/000245643. Epub 2010 Jan 8.
Endothelial progenitor cells are cells derived from the bone marrow that circulate in the bloodstream and can exhibit phenotypic characteristics of endothelial cells. They are thought to be involved in postnatal vasculogenesis and to potentially help repair injured endothelium. Circulating endothelial cells are mature endothelial cells in the circulation, and endothelial vesicles or microparticles are thought to be derived from the membranes of endothelial cells as a result of injury or activation. Recent research has focused on using these markers of endothelial injury and repair to assess the state of endothelial health. These efforts have been hampered by lack of uniformity in methodology and terminology. Recent developments in flow cytometry techniques have allowed better characterization and definition of these cells. We review the common techniques used to identify and isolate these cells, clinical studies in patients with chronic kidney disease (CKD) where they serve as markers of endothelial health and predictors of outcome, and possible mechanisms of progenitor cell dysfunction in CKD.
内皮祖细胞是源自骨髓的细胞，它们在血液中循环，并表现出内皮细胞的表型特征。它们被认为参与了出生后的血管生成，并可能有助于修复受损的内皮细胞。循环内皮细胞是循环中的成熟内皮细胞，而内皮小泡或微泡被认为是由于损伤或激活而从内皮细胞的膜上衍生而来的。最近的研究集中在使用这些内皮损伤和修复的标志物来评估内皮健康状况。这些努力受到方法学和术语缺乏一致性的阻碍。最近在流式细胞术技术方面的进展使得更好地对这些细胞进行了特征描述和定义。我们回顾了用于识别和分离这些细胞的常用技术、在慢性肾脏病 (CKD) 患者中作为内皮健康标志物和预后预测因子的临床研究，以及 CKD 中祖细胞功能障碍的可能机制。
