成人肺移植患者中与 Epstein-Barr 病毒相关的子宫平滑肌肉瘤。
Epstein-Barr virus-associated uterine leiomyosarcoma in an adult lung transplant patient.
机构信息
From the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington; the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington Hospital Medical Center, Washington, DC and; the Advanced Lung Disease and Transplant Center, Inova Fairfax Hospital, Falls Church, Virginia.
出版信息
Obstet Gynecol. 2010 Feb;115(2 Pt 2):434-436. doi: 10.1097/AOG.0b013e3181c51ed0.
BACKGROUND
Multiple viruses have been associated with carcinogenesis in solid-organ transplant patients. Although Epstein-Barr virus (EBV) has been associated with lymphomas in immunocompromised patients, an association with smooth muscle tumors recently has been described.
CASE
An EBV immunoglobulin G-positive woman underwent bilateral lung transplant for sarcoidosis. She was placed on immunosuppression and prophylaxis for opportunistic infections. She presented 5 months later with an EBV-positive uterine leiomyosarcoma. Postoperative therapy included a decrease in immunosuppression and antiviral therapy. Recurrence was noted after 1 year; the patient developed sepsis while undergoing chemotherapy and declined further therapy.
CONCLUSION
Epstein-Barr virus-associated leiomyosarcoma can occur in the uterus in immunosuppressed patients.
背景
多种病毒与实体器官移植患者的致癌作用有关。虽然 EBV（Epstein-Barr virus）与免疫功能低下患者的淋巴瘤有关，但最近已描述了其与平滑肌肿瘤的关联。
病例
一名 EBV 免疫球蛋白 G 阳性的女性因结节病接受了双侧肺移植。她接受了免疫抑制和机会性感染预防治疗。 5 个月后，她出现了 EBV 阳性的子宫平滑肌肉瘤。术后治疗包括减少免疫抑制和抗病毒治疗。 1 年后发现复发；患者在接受化疗时发生败血症，并拒绝进一步治疗。
结论
在免疫抑制患者中，子宫可发生 EBV 相关平滑肌肉瘤。
Zotero 插件