Else-Kröner-Fresenius Center of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Horm Metab Res. 2010 Apr;42(4):290-4. doi: 10.1055/s-0029-1243637. Epub 2010 Jan 21.
Exercise is an important part of obesity treatment concepts to support fat mobilisation from adipose tissue and also fat oxidation nolich is impaired in obese subjects. In normal weight subjects it is well known that stimulation of plasma insulin levels by a carbohydrate meal can inhibit lipolysis and subsequent fat oxidation. Since obese subjects frequently have elevated basal and postprandial insulin levels the effect of carbohydrate- and protein-rich test meals on exercise-induced activation of lipolysis is of special interest. Twenty obese subjects performed bicycle exercise for 30 min in the fasted state, 30 min after a carbohydrate-or a protein-rich meal, and 120 min after the carbohydrate meal (n=12), respectively, at low intensity. Activation of lipolysis was assessed by plasma glycerol levels. In addition, plasma insulin, glucose, and lactate concentrations were determined. In comparison to the fasted state, the carbohydrate meal suppressed activation of lipolysis. Following the protein meal, exercise led to an attenuated but significant increase of glycerol levels. A similar rise was observed when the carbohydrate meal was ingested 2 h prior to the exercise bout. To improve exercise-induced lipolysis and subsequent fat oxidation during low-intensity exercise obese subjects should not ingest carbohydrates immediately before exercise. Hunger sensations should be satisfied with protein-rich food. When carbohydrates are consumed 2 h prior to exercise its lipolytic effect is comparable to the protein meal. These data are useful in every day dietary counselling and might help to improve weight loss during obesity treatment.
运动是肥胖治疗概念的重要组成部分，有助于支持脂肪从脂肪组织中动员，并且肥胖患者的脂肪氧化功能受损。在正常体重人群中，众所周知，碳水化合物餐刺激血浆胰岛素水平可以抑制脂肪分解和随后的脂肪氧化。由于肥胖患者通常具有升高的基础和餐后胰岛素水平，因此富含碳水化合物和蛋白质的测试餐对运动诱导的脂肪分解激活的影响具有特殊意义。20 名肥胖受试者在空腹状态下进行 30 分钟自行车运动，在进食碳水化合物或富含蛋白质的餐后 30 分钟，以及碳水化合物餐后 120 分钟（n=12），分别以低强度进行。通过血浆甘油水平评估脂肪分解的激活。此外，还测定了血浆胰岛素、葡萄糖和乳酸浓度。与空腹状态相比，碳水化合物餐抑制了脂肪分解的激活。在摄入蛋白质餐后，运动导致甘油水平的衰减但显著增加。当在运动前 2 小时摄入碳水化合物餐时，也观察到类似的上升。为了在低强度运动期间改善运动诱导的脂肪分解和随后的脂肪氧化，肥胖患者不应在运动前立即摄入碳水化合物。应通过富含蛋白质的食物来满足饥饿感。当碳水化合物在运动前 2 小时消耗时，其脂肪分解作用与蛋白质餐相当。这些数据在日常饮食咨询中很有用，并可能有助于在肥胖治疗期间减轻体重。
