Department of Obstetrics, São Paulo Federal University (UNIFESP), São Paulo, SP, Brazil.
Am J Perinatol. 2010 Jun;27(6):501-5. doi: 10.1055/s-0030-1247607. Epub 2010 Jan 21.
We sought to establish normative data for three-dimensional ultrasound (3DUS) first-trimester embryonic volume using the extended imaging virtual organ computer-aided analysis (XI VOCAL) technique. This cross-sectional study involved 64 normal pregnancies at 7 to 10 + 6 weeks' gestation. Embryonic volume was obtained on 3DUS using the XI VOCAL technique with manual outline of 10 sequential planes. The mean, median, standard deviation, and maximum and minimum values were obtained for each week calculated. Polynomial regression models adjusted by the determination coefficient (R(2)) were created to assess the correlation between embryonic volume and gestational age (GA) and crown rump length (CRL). The intraclass correlation coefficient (ICC) was used to calculate inter- and intraobserver reproducibility. Mean embryonic volume went from 0.20 cm(3) (range 0.10 to 0.89 cm(3)) to 5.12 cm(3) (range 2.90 to 5.98 cm(3)). Embryonic volume was strongly correlated with GA (R(2) = 0.84) and with CRL (R(2) = 0.87). There was a good inter- and intraobserver reproducibility of embryonic volume with ICC = 0.999 and 0.995, respectively. Reference range for 3DUS first-trimester embryonic volume using the XI VOCAL technique were generated for pregnancies at 7 to 10 + 6 weeks, with high inter- and intraobserver reproducibility.
我们旨在使用扩展成像虚拟器官计算机辅助分析（XI VOCAL）技术为三维超声（3DUS）的孕早期胚胎体积建立参考值。这是一项横断面研究，共纳入了 64 例孕 7-10+6 周的正常妊娠。使用 XI VOCAL 技术，手动描绘 10 个连续平面获取胚胎体积。计算出每周的平均值、中位数、标准差、最大值和最小值。通过决定系数（R(2)）建立多项式回归模型，评估胚胎体积与孕龄（GA）和头臀长（CRL）之间的相关性。使用组内相关系数（ICC）评估观察者间和观察者内的可重复性。胚胎体积从 0.20cm(3)（范围 0.10-0.89cm(3)）增加到 5.12cm(3)（范围 2.90-5.98cm(3)）。胚胎体积与 GA（R(2) = 0.84）和 CRL（R(2) = 0.87）高度相关。胚胎体积具有良好的观察者间和观察者内可重复性，ICC 分别为 0.999 和 0.995。利用 XI VOCAL 技术，为孕 7-10+6 周的妊娠建立了 3DUS 孕早期胚胎体积的参考范围，具有较高的观察者间和观察者内可重复性。
