College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
J Nat Prod. 2010 Feb 26;73(2):167-71. doi: 10.1021/np900538r.
Four new bis-beta-carboline alkaloids, quassidines A-D (1-4), together with a known alkaloid, picrasidine C (5), were isolated from the stems of Picrasma quassioides. Quassidine A (1) is the first reported bis-beta-carboline alkaloid possessing a novel cyclobutane moiety. The structures of the new compounds were determined on the basis of their 1D and 2D NMR and X-ray diffraction data. A possible biogenetic pathway for these alkaloids was proposed, and all compounds were evaluated for anti-inflammatory activity. Only quassidine A (1) showed weak activity.
从青牛胆（Picrasma quassioides）的茎中分离得到了四个新的双-β-咔啉生物碱，分别为 quassidines A-D（1-4），以及一个已知的生物碱 picrasidine C（5）。化合物 1 是第一个报道的具有新型环丁烷部分的双-β-咔啉生物碱。新化合物的结构是基于它们的 1D 和 2D NMR 和 X 射线衍射数据确定的。提出了这些生物碱的可能生物合成途径，并对所有化合物进行了抗炎活性评估。只有 quassidine A（1）表现出较弱的活性。
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