Department of Immunology, Medical Faculty, Medical School and Medicinal Plant Research Center, Shahed University, Tehran, Iran.
Immunopharmacol Immunotoxicol. 2010 Sep;32(3):450-3. doi: 10.3109/08923970903513121.
The tendency of immune response toward either Th1 or Th2 cytokine pattern can cause a number of pathologic conditions. Multiple sclerosis is postulated to be a Th1-type cell-mediated autoimmune disease. MS14--an Iranian natural product--seems to possess anti-inflammatory properties. Thus, we studied the effect of orally administered MS14 on Th2 cytokines (IL-5 and IL-10) in normal Balb/C mice (100 mg/kg; 5 days). The result indicated that activated splenocytes of MS14 group produced significantly more IL-5 and IL-10 (3-4 times in comparison with control group mice). MS14 could upregulate Th2 cytokine and thereby it may possess immunoregulatory properties probably useful in treatment of some diseases.
免疫反应向 Th1 或 Th2 细胞因子模式的倾向可导致多种病理状况。多发性硬化症被认为是一种 Th1 型细胞介导的自身免疫性疾病。MS14（一种伊朗天然产物）似乎具有抗炎特性。因此，我们研究了口服 MS14 对正常 Balb/C 小鼠（100mg/kg；5 天）Th2 细胞因子（IL-5 和 IL-10）的影响。结果表明，MS14 组的激活脾细胞产生了显著更多的 IL-5 和 IL-10（与对照组小鼠相比增加了 3-4 倍）。MS14 可以上调 Th2 细胞因子，因此它可能具有免疫调节特性，可能对某些疾病的治疗有用。
