Siebert U, Hasselmeier I, Wohlsein P
Research and Technology Centre Westcoast (FTZ), University of Kiel, Büsum, Germany.
J Comp Pathol. 2010 Aug-Oct;143(2-3):179-84. doi: 10.1016/j.jcpa.2009.12.011. Epub 2010 Jan 21.
Neoplastic diseases in cetaceans are considered relatively uncommon. This report describes a gastric squamous cell carcinoma in an adult male harbour porpoise (Phocoena phocoena) stranded on the North Sea coast of Schleswig-Holstein, Germany. The tumour arose from the squamous epithelium of the first compartment of the stomach and metastases were found in the pulmonary and retropharyngeal lymph nodes, liver, lung and brain. Neoplastic epithelial cells expressed cytokeratin (CK) 5, CK6 and CK10. This pattern of CK expression did not differ from that of normal porpoise squamous gastric mucosa and partially shares the CK profile of human oesophageal epithelium. Tumour cells strongly expressed p53, suggesting a possible role for this tumour suppressor gene in tumourigenesis.
鲸类动物的肿瘤性疾病被认为相对不常见。本报告描述了一头搁浅在德国石勒苏益格 - 荷尔斯泰因州北海海岸的成年雄性港湾鼠海豚（Phocoena phocoena）的胃鳞状细胞癌。肿瘤起源于胃第一部分的鳞状上皮，在肺和咽后淋巴结、肝脏、肺和脑发现了转移灶。肿瘤上皮细胞表达细胞角蛋白（CK）5、CK6和CK10。这种CK表达模式与正常鼠海豚鳞状胃黏膜的模式没有差异，并且部分与人类食管上皮的CK谱相同。肿瘤细胞强烈表达p53，表明该肿瘤抑制基因在肿瘤发生中可能起作用。
