Moody D M, Santamore W P, Bell M A
Clin Neurosurg. 1991;37:372-87.
A mathematical model of pressure/flow relationships in straight and tortuous intracerebral arterioles is presented. Using this model, it is predicted that patients with severe tortuosity would never be able to tolerate an appreciable decrease in MAP. This morphological alteration may explain the inability of a few hypertensive and normotensive elderly patients to tolerate periods of mild reductions in blood pressure. The alkaline phosphatase histochemical staining technique is potentially an excellent method of establishing the identity of deep white matter signal alterations seen on MRI because of its ability to trace the vascular supply from the brain surface to the lesion.
本文提出了一个关于直的和迂曲的脑内小动脉压力/流量关系的数学模型。利用该模型预测，严重迂曲的患者将永远无法耐受平均动脉压（MAP）的显著降低。这种形态学改变可能解释了一些高血压和正常血压的老年患者无法耐受轻度血压降低时期的原因。碱性磷酸酶组织化学染色技术因其能够追踪从脑表面到病变的血管供应，潜在地是一种确定MRI上所见深部白质信号改变特征的优秀方法。
