关于正确分配植物前列腺素和出现新的前列腺素环系统的警示说明。

A cautionary note on the correct structure assignment of phytoprostanes and the emergence of a new prostane ring system.

机构信息

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo namesti 2, 16610 Prague, Czech Republic.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2010 Feb-Mar;82(2-3):83-6. doi: 10.1016/j.plefa.2009.10.005. Epub 2010 Jan 22.

DOI:10.1016/j.plefa.2009.10.005

PMID:20097050

Abstract

Considerable confusion exists about the correct structural representation of phytoprostanes (PhytoP). Improper use of the different nomenclature systems leads to incorrect structure assignment of PhytoP, which results in wrong synthetic approaches to these molecules and may lead to wrong rationalization of biological activity. A new prostane ring system was found, which is proposed to be termed L(1)-PhytoP or L(2)-IsoP, respectively.

摘要

关于植物前列腺素（PhytoP）的正确结构表示形式存在很大的混淆。不同命名系统的不当使用导致 PhytoP 的结构分配不正确，这导致了这些分子的错误合成方法，并可能导致对生物活性的错误合理化。发现了一种新的前列腺素环系统，分别提议将其命名为 L(1)-PhytoP 或 L(2)-IsoP。