Julius-von-Sachs-Institut fuer Biowissenschaften, Pharm. Biologie, Biozentrum, Universitaet Wuerzburg, Julius-von-Sachs-Platz 2, 97082 Wuerzburg, Germany.
Prostaglandins Leukot Essent Fatty Acids. 2010 Feb-Mar;82(2-3):71-81. doi: 10.1016/j.plefa.2009.11.007. Epub 2010 Jan 19.
Do we have to bother about the isoprostane nomenclature? The widely accepted IUPAC isoprostane nomenclature provides an unambiguous and systematic terminology to name all theoretical possible isoprostanes. However, the currently accepted nomenclature system provides an unnatural framework which is not well suited to address certain biologically relevant questions. Artificial categorization of isoprostanoids into prostanoid families disrupts prostaglandin-ring core structures needed to describe biogenetic precursor-product relationships. In addition, the IUPAC system defines isoprostanoid families which comprise chemically heterogeneous isoprostanoids which largely differ in their physicochemical properties from those of the corresponding prostaglandins. As a result of this, alternative nomenclature systems such as the phytoprostane nomenclature system overcoming some inherent problems of the IUPAC nomenclature are still in use. However, different naming of isoprostanoids especially the classification of prostanoid family names has created considerable confusion. Therefore, a cautionary note on the current use of different nomenclature systems is necessary.
我们是否需要为异前列烷命名而烦恼？被广泛接受的 IUPAC 异前列烷命名法为所有理论上可能的异前列烷提供了一个明确而系统的术语。然而，目前接受的命名系统提供了一个不自然的框架，不太适合解决某些与生物学相关的问题。将异前列烷酸人为地划分为前列腺素家族会破坏描述生物发生前体-产物关系所需的前列腺素环核心结构。此外，IUPAC 系统定义了异前列烷酸家族，其中包含化学异构的异前列烷酸，它们在物理化学性质上与相应的前列腺素有很大的不同。因此，替代命名系统，如植物前列腺烷酸命名系统，克服了 IUPAC 命名系统的一些固有问题，仍在使用中。然而，异前列烷酸的不同命名，特别是前列腺素家族名称的分类，已经造成了相当大的混乱。因此，有必要对当前使用的不同命名系统提出警告。
