酶促化学合成 1-脱氮吡哆醛 5′-磷酸。
Chemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.
机构信息
Department of Chemistry, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
出版信息
Bioorg Med Chem Lett. 2010 Feb 15;20(4):1352-4. doi: 10.1016/j.bmcl.2010.01.002. Epub 2010 Jan 7.
Abstract
The first synthesis of 1-deaza-pyridoxal 5'-phosphate (2-formyl-3-hydroxy-4-methylbenzyl phosphate) is described. The chemoenzymatic approach described here is a reliable route to this important isosteric pyridoxal phosphate analogue. This work enables elucidation of the role of the pyridine nitrogen in pyridoxal 5'-phosphate dependent enzymes.
摘要
本文首次合成了 1-脱氮吡哆醛 5'-磷酸（2-醛基-3-羟基-4-甲基苄基磷酸）。这里描述的化学生酶方法是获得这种重要的等排吡哆醛磷酸类似物的可靠途径。这项工作使人们能够阐明吡啶氮在吡哆醛 5'-磷酸依赖酶中的作用。
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