Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland.
Behav Brain Res. 2010 May 1;209(1):174-8. doi: 10.1016/j.bbr.2010.01.021. Epub 2010 Jan 25.
The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.
杏仁核谷氨酸能受体（GluRs）在维持神经性疼痛的感觉和情感成分中的作用通过评估杏仁核给予各种谷氨酸化合物后，单丝诱导的肢体退缩反应（感觉疼痛）和回避性位置条件反射行为（情感疼痛）在神经损伤动物中的作用来研究。结果表明，杏仁核组 I 代谢型谷氨酸能受体（mGluR(1)和 mGluR(5)）和 NMDA-R 的内源性激活有助于维持神经性疼痛的感觉和情感成分。杏仁核组 I mGluRs 的主要作用是促进情感样疼痛行为。
