Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, China.
Brain Res Bull. 2010 Apr 5;81(6):590-4. doi: 10.1016/j.brainresbull.2010.01.008. Epub 2010 Jan 25.
Ischemic stroke (IS) is a major cause of morbidity and mortality around the world. Interleukin-18 (IL-18) plays an important role in the pathogenesis of IS and IL-18 promoter polymorphisms have been shown to be associated with levels of expression of IL-18. We investigated the association of two functional polymorphisms in IL-18 promoter, -607C/A (rs1946518) and -137G/C (rs187238), with the risk of ischemic stroke in a Han Chinese population of 423 patients and 384 healthy controls matched for sex and age. The results revealed that the -607C allele was associated with an increased risk of IS with an odds ratios (OR) of 1.358 (P = 0.002, power = 100%) and the presence of the -137G allele was correlated with increased the risk of IS in the subtype of patients with large artery atherosclerosis (LAA) (OR = 1.583, P = 0.02, power = 94%). Patients with the -607C/-137G haplotype also had significantly increased risk of IS compared to controls (OR = 1.341, P = 0.005, power = 100%). Our findings suggest that these functional polymorphisms in the IL-18 promoter are involved in development of IS in the Han Chinese population.
缺血性脑卒中（IS）是全世界发病率和死亡率的主要原因。白细胞介素-18（IL-18）在 IS 的发病机制中起重要作用，并且已经表明 IL-18 启动子多态性与 IL-18 的表达水平相关。我们研究了 IL-18 启动子中的两个功能多态性，-607C/A（rs1946518）和-137G/C（rs187238）与汉族人群中缺血性脑卒中的风险之间的关联，该人群包括 423 例患者和 384 例性别和年龄匹配的健康对照者。结果表明，-607C 等位基因与 IS 风险增加相关，比值比（OR）为 1.358（P=0.002，功率=100%），-137G 等位基因与大动脉粥样硬化（LAA）亚型患者的 IS 风险增加相关（OR=1.583，P=0.02，功率=94%）。与对照组相比，携带-607C/-137G 单体型的患者发生 IS 的风险也显著增加（OR=1.341，P=0.005，功率=100%）。我们的研究结果表明，IL-18 启动子中的这些功能性多态性参与了汉族人群中 IS 的发生。
