Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, Shandong, China; Pharmic Department, Medical College of Qingdao University, Qingdao 266021, Shandong, China.
J Ethnopharmacol. 2010 Apr 21;128(3):590-3. doi: 10.1016/j.jep.2010.01.027. Epub 2010 Jan 25.
Xiao-Ban-Xia-Tang (XBXT), a traditional Chinese herbal medicine, has been used in China for more than 2000 years, and proved to be effective on various cases of vomiting in the clinic.
To investigate the antiemetic effect of XBXT on cisplatin-induced acute and delayed emesis and its effective mechanism on Neurokinin-1 receptor (NK(1)-R) in the new vomiting model of minks.
Minks were randomly divided into the normal group, cisplatin group, cisplatin + ondansetron group, cisplatin + low-dose XBXT group and cisplatin + high-dose XBXT group. The antiemetic effect of drugs was investigated in the vomiting model of minks induced by cisplatin (6mgkg(-1), i.p.) in 72h observation, and the expression of NK(1)-R in the area postrema and ileum was measured by Western blot.
The frequency cisplatin induces retching and vomiting was significantly reduced by pretreatment with XBXT in a dose-dependent manner during the 0-24-h and 24-72-h periods (P<0.05), and XBXT exhibited effective dose-dependent (P<0.05) inhibition on the increase of expression levels of NK1 receptor in both the ileum and area postrema.
XBXT has good activity against cisplatin-induced acute and delayed emesis in minks possibly by inhibiting central or peripheral increase of NK(1)-R.
消斑消瘕汤（XBXT）是一种中药，在中国已经使用了 2000 多年，在临床上对各种呕吐病例均有疗效。
研究 XBXT 对顺铂诱导的急性和迟发性呕吐的止吐作用及其对新型水貂呕吐模型中神经激肽-1 受体（NK（1）-R）的有效作用机制。
水貂随机分为正常组、顺铂组、顺铂+昂丹司琼组、顺铂+低剂量 XBXT 组和顺铂+高剂量 XBXT 组。采用顺铂（6mgkg（-1），腹腔注射）诱导水貂呕吐模型，观察药物的止吐作用，并用 Western blot 法测定后区和回肠 NK（1）-R 的表达。
XBXT 预处理可显著减少顺铂诱导的水貂在 0-24 小时和 24-72 小时期间的恶心和呕吐次数，呈剂量依赖性（P<0.05），并且 XBXT 对回肠和后区 NK1 受体表达水平的升高具有有效的剂量依赖性抑制作用（P<0.05）。
XBXT 对水貂顺铂诱导的急性和迟发性呕吐具有良好的活性，可能通过抑制中枢或外周 NK（1）-R 的增加而起作用。
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