Yue Wang, Zhang Fang, Wang Lei, Fang Xuan, Liu Yan-xia, Minami Masaru
Department of Pharmacology, Medical College of Qingdao University, Qingdao University, Qingdao 266021, China.
Yao Xue Xue Bao. 2003 Feb;38(2):89-91.
To establish a new, reliable vomiting model in minks.
Adult male minks (Mustela vison) were randomly divided into groups (n = 6). Cisplatin, apomorphine, copper sulfate and X-radiation were used to establish vomiting model. Retching and vomiting were observed after the vomiting models were given anti-vomiting agents. After the behavioral experiment, assay of 5-HT in the ileum was performed by immunohistologic method.
Cisplatin 7.5 mg.kg-1 i.p., apomorphine 1.6 mg.kg-1 s.c. and copper sulfate 40 mg.kg-1 ig were shown to evoke vomiting. Retching and vomiting were significantly inhibited in ondansetron and metoclopramide pretreated minks (P < 0.05, P < 0.01).
As a new vomiting model, minks may be of great value in studying vomiting mechanism and screening new antiemetic drugs.
在水貂中建立一种新的、可靠的呕吐模型。
将成年雄性水貂（鼬属水貂）随机分组（n = 6）。使用顺铂、阿扑吗啡、硫酸铜和X射线建立呕吐模型。在给呕吐模型使用止吐剂后，观察干呕和呕吐情况。行为实验后，采用免疫组织学方法检测回肠中5-羟色胺（5-HT）。
腹腔注射7.5 mg.kg-1顺铂、皮下注射1.6 mg.kg-1阿扑吗啡和灌胃40 mg.kg-1硫酸铜可引起呕吐。预先用昂丹司琼和胃复安处理的水貂干呕和呕吐明显受到抑制（P < 0.05，P < 0.01）。
作为一种新的呕吐模型，水貂在研究呕吐机制和筛选新型止吐药物方面可能具有重要价值。
