Center for Reproductive Medicine, Department of Pathology, Dutch-Speaking Free University Brussels, Brussels, Belgium.
Fertil Steril. 2010 Nov;94(6):2054-8. doi: 10.1016/j.fertnstert.2009.11.036. Epub 2010 Jan 25.
To assess whether there is a difference in the ongoing pregnancy rate after transferring frozen-thawed embryos in natural cycles with spontaneous LH-P rise compared with natural cycles controlled by hCG for final oocyte maturation and ovulation.
Randomized controlled trial.
Tertiary referral center.
PATIENT(S): A total of 168 patients were assigned randomly to undergo frozen ET on day 3 from October 2007 until November 2008. Finally, analysis was performed in 124 patients; 61 belonged to the spontaneous LH group and 63 to the hCG group.
INTERVENTION(S): In the spontaneous LH group the transfer was planned 5 days after the LH surge. In the hCG group, the cryopreserve ET was planned 5 days after the administration of 5000 IU of hCG, when an endometrial thickness of ≥7 mm and a follicle of ≥17 mm were present on ultrasound examination.
MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate.
RESULT(S): The study was terminated early, when a prespecified interim analysis found a significantly higher ongoing pregnancy rate in the spontaneous LH group as compared with the hCG group (31.1% vs. 14.3%; difference 16.9%, 95% confidence interval 4.4%-28.8%).
CONCLUSION(S): The results suggest the superiority of the natural cycle as compared with the natural cycle controlled by hCG administration in cryothawed ET cycles.
评估在自然周期中出现自发性 LH 峰后与 hCG 控制的自然周期中最终卵母细胞成熟和排卵后进行冻融胚胎移植的持续妊娠率是否存在差异。
随机对照试验。
三级转诊中心。
共有 168 名患者被随机分配在 2007 年 10 月至 2008 年 11 月进行第 3 天的冻融胚胎移植。最终，对 124 名患者进行了分析；其中 61 名属于自发性 LH 组，63 名属于 hCG 组。
在自发性 LH 组中，转移计划在 LH 峰后 5 天进行。在 hCG 组中，当超声检查显示子宫内膜厚度≥7mm 且卵泡≥17mm 时，计划在给予 5000IU hCG 后 5 天进行冷冻胚胎移植。
持续妊娠率。
研究提前终止，当预先指定的中期分析发现自发性 LH 组的持续妊娠率明显高于 hCG 组（31.1%比 14.3%；差异 16.9%，95%置信区间 4.4%-28.8%）。
结果表明，在冻融胚胎移植周期中，自然周期优于 hCG 给药控制的自然周期。
