果蝇八聚体元件和 Pdm-1 决定了核心组蛋白基因的协调转录。
Drosophila octamer elements and Pdm-1 dictate the coordinated transcription of core histone genes.
机构信息
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore.
出版信息
J Biol Chem. 2010 Mar 19;285(12):9041-53. doi: 10.1074/jbc.M109.075358. Epub 2010 Jan 22.
Abstract
We reveal a set of divergent octamer elements in Drosophila melanogaster (dm) core histone gene promoters. These elements recruit transcription factor POU-domain protein in D. melanogaster 1 (Pdm-1), which along with co-activator dmOct-1 coactivator in S-phase (dmOCA-S), activates transcription from at least the Drosophila histone 2B (dmH2B) and 4 (dmH4) promoters in a fashion similar to the transcription of mammalian histone 2B (H2B) gene activated by octamer binding transcription factor 1 (Oct-1) and Oct-1 coactivator in S-phase (OCA-S). The expression of core histone genes in both kingdoms is coordinated; however, although the expression of mammalian histone genes involves subtype-specific transcription factors and/or co-activator(s), the expression of Drosophila core histone genes is regulated by a common module (Pdm-1/dmOCA-S) in a directly coordinated manner. Finally, dmOCA-S is recruited to the Drosophila histone locus bodies in the S-phase, marking S-phase-specific transcription activation of core histone genes.
摘要
我们在果蝇（dm）核心组蛋白基因启动子中揭示了一组发散的八聚体元件。这些元件招募果蝇 1（Pdm-1）中的转录因子 POU 结构域蛋白，该蛋白与 S 期的共激活因子 dmOct-1 共激活因子（dmOCA-S）一起，以类似于转录因子 octamer 结合转录因子 1（Oct-1）和 S 期的 Oct-1 共激活因子（OCA-S）激活哺乳动物组蛋白 2B（H2B）基因转录的方式，从至少果蝇组蛋白 2B（dmH2B）和 4（dmH4）启动子激活转录。两个王国的核心组蛋白基因的表达是协调的；然而，尽管哺乳动物组蛋白基因的表达涉及亚型特异性转录因子和/或共激活因子，但果蝇核心组蛋白基因的表达受共同模块（Pdm-1/dmOCA-S）的直接协调调节。最后，dmOCA-S 在 S 期被募集到果蝇组蛋白基因座体，标记核心组蛋白基因的 S 期特异性转录激活。
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