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[血液透析患者的运动:一项文献系统综述]

[Exercise in haemodyalisis patients: a literature systematic review].

作者信息

Segura-Ortí Eva

机构信息

Departamento de Fisioteerapia, Universidad CEU Cardenal Herrera, Moncada, Valencia.

出版信息

Nefrologia. 2010;30(2):236-46. doi: 10.3265/Nefrologia.pre2010.Jan.10229. Epub 2010 Jan 21.

Abstract

Exercise as a therapeutic tool used in End-stage renal disease patients (ESRD) in hemodialysis (HD) is not routinately applied, as it occurs with cardiac or respiratory patients. Lack of awareness of research in this field may contribute to the current situation. Thus, the aims of this review are: 1) to systematically review the literature of exercise training on adult HD patients or patients at a pre-HD stage; 2) to show the evidence on the benefits of exercise for counteracting physiological, functional and psychological impairments found even in older ESRD patients; 3) to recommend requirements of future research in order to include exercise prescription in the HD patients treatment. The Data bases reviewed from 2005 to 2009 were: MEDLINE (Ovid), CINAHL (EBSCOHost), SportDicus (EBSCOHost), Academic Search Complete (EBSCOHost), Fuente Académica (EBSCOHost), MedicLatina (EBSCOHost), PEDro y PubMed. Additionally, references from identified articles, several reviews on ESRD and abstracts to Nephrology Congresses were also reviewed. Randomized Controlled Trials on aerobic, strength and combined programs for HD patients were selected. Data from the studies was compiled and Van Tulder criteria were used for methodological quality assessment. Metanalysis included 6 studies on aerobic exercise, 2 on strength exercise and 5 on combined exercise programs. 640 patients were included in 16 included studies. Effects on physical function, health related quality of life and other secondary measurements were summarized by the Standardized Mean Difference (SMD) Moderate evidence exists on positive effects of aerobic training on peak oxygen consumption at the graded exercise test (SMD 6.55; CI 95%: 4.31-8.78). There is high evidence on positive effects of strength training on health related quality of life (SMD 11.03; CI 95%: 5.63-16.43). Finally, moderate evidence exists on positive effects of combined exercise on peak oxygen consumption at the graded exercise test (SMD 5.57; CI 95%: 2.52-8.61). Summarizing, moderate evidence exists on the improvement on exercise capacity of aerobic training, isolated or combined with strength training. Strength training improves health related quality of life, functional capacity and lower limbs strength. Future studies should clarify which out of the three modalities results in higher benefits for HD patients.

摘要

作为一种治疗手段,运动在接受血液透析(HD)的终末期肾病(ESRD)患者中并未像在心脏病或呼吸系统疾病患者中那样得到常规应用。对该领域研究的认识不足可能导致了当前这种情况。因此,本综述的目的是:1)系统回顾关于成年HD患者或HD前期患者运动训练的文献;2)展示运动对于对抗甚至在老年ESRD患者中发现的生理、功能和心理损害有益的证据;3)推荐未来研究的要求,以便将运动处方纳入HD患者的治疗中。2005年至2009年所检索的数据库包括:MEDLINE(Ovid)、CINAHL(EBSCOHost)、SportDicus(EBSCOHost)、Academic Search Complete(EBSCOHost)、Fuente Académica(EBSCOHost)、MedicLatina(EBSCOHost)、PEDro以及PubMed。此外,还对已识别文章的参考文献、几篇关于ESRD的综述以及肾脏病学大会的摘要进行了回顾。选取了关于HD患者有氧运动、力量训练和综合训练项目的随机对照试验。汇总了研究数据,并使用范图尔德标准进行方法学质量评估。荟萃分析纳入了6项关于有氧运动的研究、2项关于力量训练的研究和5项关于综合训练项目的研究。16项纳入研究共纳入了640名患者。通过标准化均数差(SMD)总结了对身体功能、健康相关生活质量和其他次要测量指标的影响。有中等证据表明有氧运动对分级运动试验中的峰值耗氧量有积极影响(SMD 6.55;95%置信区间:4.31 - 8.78)。有充分证据表明力量训练对健康相关生活质量有积极影响(SMD 11.03;95%置信区间:5.63 - 16.43)。最后,有中等证据表明综合训练对分级运动试验中的峰值耗氧量有积极影响(SMD 5.57;95%置信区间:2.52 - 8.61)。总之,有中等证据表明有氧运动能力的改善,无论是单独进行还是与力量训练相结合。力量训练可改善健康相关生活质量、功能能力和下肢力量。未来的研究应阐明这三种方式中哪一种对HD患者益处更大。

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