Nephrology Service, Hospital General de México "Dr. Eduardo Liceaga", Mexico City 06726, Mexico.
Department of Kinesiology and Community Health, University of Illinois, Urbana, IL 61820, USA.
Nutrients. 2022 Jul 19;14(14):2946. doi: 10.3390/nu14142946.
Oral nutritional supplementation (ONS) with or without exercise (EX) could improve muscle mass (MM) in chronic kidney disease.
Patients were randomized into two groups: (1) ONS and (2) ONS + EX. Thigh muscle area (cm) and intramuscular lipid content via attenuation were evaluated at baseline and 6 months with computed tomography (CT) to measure MM quantity and quality. Physical function was measured by six-minute walk test (6 MWT), gait speed, handgrip strength (HGS), and Time Up and Go test (TUG) at baseline and 3 and 6 months.
The ONS group (= 14) showed statistically significant improvement in gait speed and HGS; ONS + EX group ( = 10) showed differences in gait speed, in 6 MWT, and HGS. In the ANOVA (3 times × 2 groups), no differences were observed between groups. Greater effect sizes in favor to ONS + EX group were observed in the 6 MWT (d = 1.02) and TUG test (d = 0.63). Muscle quality at six months revealed a significant trend in favor of the EX-group ( = 0.054).
Both groups had improved physical function, and greater effect sizes were seen in the ONS + EX group for the 6 MWT and TUG test. Neither MM quantity or quality was improved in either group.
口服营养补充（ONS）联合或不联合运动（EX）可改善慢性肾脏病患者的肌肉量（MM）。
患者随机分为两组：（1）ONS 组，（2）ONS+EX 组。基线和 6 个月时采用计算机断层扫描（CT）评估大腿肌肉面积（cm）和肌肉内脂质含量衰减，以测量 MM 量和质。基线和 3、6 个月时采用 6 分钟步行试验（6 MWT）、步态速度、握力（HGS）和起立-行走测试（TUG）评估身体功能。
ONS 组（n=14）的步态速度和 HGS 有统计学显著改善；ONS+EX 组（n=10）的步态速度、6 MWT 和 HGS 有差异。在 ANOVA（3 次×2 组）中，两组之间无差异。ONS+EX 组在 6 MWT（d=1.02）和 TUG 测试（d=0.63）中观察到更大的有利于 ONS+EX 组的效应量。6 个月时肌肉质量有向 EX 组显著改善的趋势（=0.054）。
两组的身体功能均有改善，ONS+EX 组在 6 MWT 和 TUG 测试中观察到更大的效应量。两组的 MM 量和质均无改善。
