Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel de Unamuno, Salamanca, Spain.
Mar Drugs. 2009 Dec 23;7(4):833-49. doi: 10.3390/md7040833.
Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis, and also an important cytotoxic activity against several cancer cell lines, including multidrug-resistant ones. Of particular interest in this context are the asmarines (tetrahydro[1,4]diazepino[1,2,3-g,h]purines), which have shown potent antiproliferative activity against several types of human cancer cell lines. This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives.
从 Agela 属、Raspailia 属等多种海绵体中分离得到的 Agelasines、Asmarines 和相关化合物是具有混合萜类-嘌呤结构的天然产物。一些 Agelasine 类似物和相关结构对原生动物表现出很高的一般毒性，并对多种物种表现出广谱抗菌活性，包括结核分枝杆菌，并且对包括多药耐药性在内的几种癌细胞系也具有重要的细胞毒性活性。在这方面特别有趣的是 Asmarines（四氢[1,4]二氮杂[1,2,3-g,h]嘌呤），它对几种类型的人类癌细胞系表现出很强的抗增殖活性。本综述总结了海洋烷基嘌呤及其生物活性衍生物的分离来源、化学和生物活性。
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