Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju 27478, Korea.
School of Bio-Science and Food Engineering, Changchun University of Science and Technology, Changchun 130-600, China.
Mar Drugs. 2018 May 12;16(5):160. doi: 10.3390/md16050160.
This review focuses on marine compounds with anti-prostate cancer properties. Marine species are unique and have great potential for the discovery of anticancer drugs. Marine sources are taxonomically diverse and include bacteria, cyanobacteria, fungi, algae, and mangroves. Marine-derived compounds, including nucleotides, amides, quinones, polyethers, and peptides are biologically active compounds isolated from marine organisms such as sponges, ascidians, gorgonians, soft corals, and bryozoans, including those mentioned above. Several compound classes such as macrolides and alkaloids include drugs with anti-cancer mechanisms, such as antioxidants, anti-angiogenics, antiproliferatives, and apoptosis-inducing drugs. Despite the diversity of marine species, most marine-derived bioactive compounds have not yet been evaluated. Our objective is to explore marine compounds to identify new treatment strategies for prostate cancer. This review discusses chemically and pharmacologically diverse marine natural compounds and their sources in the context of prostate cancer drug treatment.
这篇综述重点介绍了具有抗前列腺癌特性的海洋化合物。海洋生物种类独特，具有发现抗癌药物的巨大潜力。海洋资源在分类上多种多样，包括细菌、蓝藻、真菌、藻类和红树林。海洋来源的化合物，包括核苷酸、酰胺、醌、聚醚和肽，是从海绵、海鞘、柳珊瑚、软珊瑚和苔藓虫等海洋生物中分离出来的具有生物活性的化合物，上述化合物也包括在内。一些化合物类别，如大环内酯类和生物碱类，包括具有抗氧化剂、抗血管生成、抗增殖和诱导细胞凋亡等抗癌机制的药物。尽管海洋生物种类繁多，但大多数海洋来源的生物活性化合物尚未得到评估。我们的目标是探索海洋化合物，为前列腺癌的治疗寻找新的治疗策略。本综述讨论了具有化学和药理学多样性的海洋天然化合物及其在前列腺癌药物治疗方面的来源。
