Department of Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
J Magn Reson Imaging. 2010 Feb;31(2):298-304. doi: 10.1002/jmri.22044.
To evaluate the reproducibility and gender differences in cerebrovascular reactivity (CVR) measurements obtained using the blood-oxygen level dependent (BOLD) response to controlled changes in end-tidal partial pressure of carbon dioxide (PETCO(2)).
We obtained ethical approval to image 19 healthy volunteers (10 men, 9 women) on a 1.5 Tesla (T) MRI scanner twice on two separate days using identical procedures. CVR images were generated by collecting BOLD MRI data during controlled changes in PETCO(2) induced by a sequential gas delivery system.
Using the intraclass correlation coefficient (ICC), we demonstrated excellent within-day CVR measures in gray matter (GM) (ICC = 0.92) and white matter (WM) (ICC = 0.88) regions, excellent between-day reproducibility in GM (ICC = 0.81), and good between-day reproducibility in the WM (ICC = 0.66). CVR values between men and women were significantly different in the GM and WM. Men exhibited a 22 +/- 2% greater CVR in GM and a 17 +/- 2% greater CVR in WM compared with females.
Our results demonstrate the reliability of BOLD MRI CVR measurements obtained using a controlled cerebrovascular challenge. Using this technique, we also revealed significantly increased BOLD response to CO(2) in males compared with females.
评估使用血氧水平依赖（BOLD）反应来测量脑血管反应性（CVR）的可重复性和性别差异，该反应是通过控制呼气末二氧化碳分压（PETCO2）的变化来获得的。
我们在两台 1.5T 磁共振成像（MRI）扫描仪上获得了伦理批准，对 19 名健康志愿者（10 名男性，9 名女性）进行了两次成像，两次成像分别在两天进行，使用的程序完全相同。通过使用顺序气体输送系统诱导 PETCO2 的受控变化来收集 BOLD MRI 数据，从而生成 CVR 图像。
使用组内相关系数（ICC），我们在灰质（GM）（ICC = 0.92）和白质（WM）（ICC = 0.88）区域中显示出了出色的日内 CVR 测量值，在 GM 中具有出色的日间可重复性（ICC = 0.81），在 WM 中具有良好的日间可重复性（ICC = 0.66）。男性和女性的 GM 和 WM 之间的 CVR 值存在显著差异。与女性相比，男性的 GM 中的 CVR 增加了 22 +/- 2%，WM 中的 CVR 增加了 17 +/- 2%。
我们的结果证明了使用受控脑血管挑战获得的 BOLD MRI CVR 测量的可靠性。使用这种技术，我们还发现男性对 CO2 的 BOLD 反应明显高于女性。
