Renger Emely, Hauser Till-Karsten, Klose Uwe, Ernemann Ulrike, Zerweck Leonie
Department of Diagnostic and Interventional Neuroradiology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Diagnostics (Basel). 2025 Aug 3;15(15):1946. doi: 10.3390/diagnostics15151946.
: Cerebrovascular reactivity (CVR) is a key marker of cerebrovascular function, facilitating the early detection of neurovascular dysfunction. Breath-hold functional MRI (bh-fMRI) is a non-invasive method for assessing CVR. This study evaluates the reproducibility of bh-fMRI using short breath-hold periods, which are practical for clinical use. : In a prospective study, 50 healthy subjects underwent three self-paced, end-expiration bh-fMRI sessions with 9 s breath-hold periods at 3T. A 30 min break between the second and third sessions was included. The reproducibility of the percentage signal change (PSC) in predefined volumes of interest for a ±0 s, ±3 s and ±6 s interval around the cerebellar peak (IAP)) was evaluated. The intraclass correlation coefficient (ICC) and the intra-personal coefficient of variation (CV) were calculated between the individual sessions. : This study demonstrated excellent reproducibility, with an ICC (2, k) for a ±0 s IAP across all sessions at 0.887 (95% CI: 0.882-0.892). The ICC values remained within an excellent range even when the participants left the scanner between sessions. The CV for the ±0 s IAP (14.54% ± 8.54%) remained below the 33% fiducial limit. A larger IAP revealed higher ICC values but higher CV values and lower PSC values. : Bh-fMRI with 9 s breath-hold periods yields highly reproducible CVR assessments, supporting its feasibility for clinical implementation.
脑血管反应性（CVR）是脑血管功能的关键指标，有助于早期发现神经血管功能障碍。屏气功能磁共振成像（bh-fMRI）是一种评估CVR的非侵入性方法。本研究评估了使用短屏气时间的bh-fMRI的可重复性，这在临床应用中具有实际意义。：在一项前瞻性研究中，50名健康受试者在3T条件下进行了三次自主呼吸、呼气末屏气9秒的bh-fMRI检查。第二次和第三次检查之间间隔30分钟。评估了在小脑峰值周围±0秒、±3秒和±6秒间隔（IAP）的预定义感兴趣体积中信号变化百分比（PSC）的可重复性。计算了各次检查之间的组内相关系数（ICC）和个体内变异系数（CV）。：本研究显示出极佳的可重复性，所有检查中±0秒IAP的ICC（2，k）为0.887（95%CI：0.882-0.892）。即使参与者在各次检查之间离开扫描仪，ICC值仍保持在极佳范围内。±0秒IAP的CV（14.54%±8.54%）仍低于33%的基准限值。更大的IAP显示出更高的ICC值，但CV值更高，PSC值更低。：屏气9秒的bh-fMRI产生高度可重复的CVR评估结果，支持其临床应用的可行性。
