Department of Neuroradiology, Huanhu Hospital, Tianjin 300060, China.
J Magn Reson Imaging. 2010 Feb;31(2):305-8. doi: 10.1002/jmri.22053.
To study the features of proton magnetic resonance spectroscopy ((1)H-MRS) on amyotrophic lateral sclerosis (ALS) and its relation with clinical scale.
Fifteen patients with definite or probable ALS and 15 age- and gender-matched normal controls were enrolled. (1)H-MRS was performed on a 3.0 Tesla GE imaging system (GE Healthcare, Milwaukee, WI). TE-averaged Point Resolved Selective Spectroscopy was used. N-acetylaspartate (NAA), creatine (Cr), Glu, and Glx (glutamate + glutamine) values of the motor cortex and posterior limb of internal capsule were acquired. The t-test was used to compare differences between groups, and the correlations between the above values and clinical scale were analyzed.
The motor area and posterior limb of the internal capsule of ALS patients had lower NAA/Cr (1.91 +/- 0.34, 1.53 +/- 0.17) compared with normal subjects (2.23 +/- 0.33, 1.66 +/- 0.07), and the differences between groups were statistically significant (P < 0.01, 0.01). ALS patients had higher Glu/Cr (0.34 +/- 0.05, 0.29 +/- 0.06) and Glx/Cr (0.40 +/- 0.04, 0.33 +/- 0.06) compared with normal subjects (0.30 +/- 0.03, 0.25 +/- 0.04) and (0.32 +/- 0.05, 0.26 +/- 0.03), and the differences between groups were statistically significant (P < 0.01, 0.01). The Norris scale was negatively correlated with Glx/Cr of primary motor cortex by lineal correlation analysis (r = -0.75), and this correlation had statistical significance (F = 16.60; P = 0.001).
Neuronal loss and Glu+Gln increase can be detected by using proton MRS in ALS patients. (1)H-MRS is an useful tool in reflecting the characteristic changes of metabolite in ALS.
研究肌萎缩侧索硬化症（ALS）质子磁共振波谱（1H-MRS）的特点及其与临床量表的关系。
纳入 15 例明确或可能的 ALS 患者和 15 名年龄和性别匹配的正常对照者。在 3.0T GE 成像系统（GE Healthcare，Milwaukee，WI）上进行 1H-MRS。采用平均 TE 点分辨选择波谱。获取运动皮质和内囊后肢的 N-乙酰天冬氨酸（NAA）、肌酸（Cr）、谷氨酸（Glu）和谷氨酰胺（Glx）值。采用 t 检验比较组间差异，分析上述值与临床量表的相关性。
ALS 患者运动区和内囊后肢的 NAA/Cr（1.91±0.34，1.53±0.17）低于正常对照组（2.23±0.33，1.66±0.07），组间差异有统计学意义（P<0.01，0.01）。ALS 患者的 Glu/Cr（0.34±0.05，0.29±0.06）和 Glx/Cr（0.40±0.04，0.33±0.06）高于正常对照组（0.30±0.03，0.25±0.04）和（0.32±0.05，0.26±0.03），组间差异有统计学意义（P<0.01，0.01）。线性相关分析显示，诺里斯量表与原发性运动皮质的 Glx/Cr 呈负相关（r=-0.75），且相关性有统计学意义（F=16.60，P=0.001）。
ALS 患者可通过质子 MRS 检测到神经元丢失和 Glu+Gln 增加。1H-MRS 是反映 ALS 代谢物特征变化的有用工具。
