Milinković Neda Lj, Majkić-Singh Nada T, Mirković Dusko D, Beletić Andjelo D, Pejanović Svetlana D, Vujanić Svetlana T
Institute of Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia.
Clin Lab. 2009;55(9-10):333-9.
Deficient serum 25-hydroxyvitamin D [25(OH)D] may contribute to the impaired bone turnover of end stage renal disease patients. In 112 hemodialysed patients we analysed the relation between 25(OH)D and bone alkaline phosphatase (BALP), beta-CrossLaps (beta-CTx) and iPTH. We analysed parameters according to the manufacturers' instructions. We found potentially significant vitamin D deficiency: 71% of patients had 25(OH)D levels below 50 nmol/L. In patients with iPTH below 150 pg/mL (n = 57), we observed significantly low 25(OH) (p < 0.01). In addition, patients with iPTH above 300 pg/mL had higher BALP levels (p < 0.05). There were negative correlations between serum 25(OH)D and both BALP and iPTH (r = -0.225, p < 0.05 and r = -0.331, p < 0.05). Beta-CTx levels were significantly higher in patients who did not receive vitamin D supplementation (p < 0.01). In addition, reduced BALP and iPTH levels indicate decreased bone turnover. Recorded data could signify that vitamin D deficiency may contribute to the impaired bone metabolism of hemodialysis patients.
血清25-羟维生素D[25(OH)D]缺乏可能导致终末期肾病患者骨转换受损。在112例接受血液透析的患者中，我们分析了25(OH)D与骨碱性磷酸酶（BALP）、β-交联C端肽（β-CTx）和iPTH之间的关系。我们根据制造商的说明分析各项参数。我们发现存在潜在显著的维生素D缺乏：71%的患者25(OH)D水平低于50 nmol/L。在iPTH低于150 pg/mL的患者（n = 57）中，我们观察到25(OH)D显著降低（p < 0.01）。此外，iPTH高于300 pg/mL的患者BALP水平更高（p < 0.05）。血清25(OH)D与BALP和iPTH均呈负相关（r = -0.225，p < 0.05和r = -0.331，p < 0.05）。未接受维生素D补充的患者β-CTx水平显著更高（p < 0.01）。此外，BALP和iPTH水平降低表明骨转换减少。记录的数据可能表明维生素D缺乏可能导致血液透析患者骨代谢受损。
