Pielesz Anna
Wydzial Nauk o Materiałach i Srodowisku, Instytut Inzynierii Tekstyliów i Materiałów Polimerowych, Akademia Techniczno-Humanistyczna w Bielsku-Białej.
Polim Med. 2009;39(4):61-7.
Hydrogels are cross-linked three-dimensional macromolecular networks that contain a large fraction of water within their structure. One of the most important properties of alginate hydrogels, leading to their broad versatility, is their ability for controlled uptake, release and retention of molecules. This ability, in turn, is due to specific interactions of the macromolecular network with the diffusing or retained molecule, for example ions. In this study, water-soluble sodium alginates contained in active dressings Medisorb A were identified using electrophoresis on cellulose acetate CAE. The presence of guluronic acid (G) and mannuronic acid (M) residues in hydrolysates of alginic acid AA (used as reference substance) and active alginate dressings Medisorb A was also proved. "Egg-box" structures, earlier described in literature, were observed using the same technique and their interpretation was attempted. Electrophoresis on cellulose acetate was found to be a useful method for examining alginate-based biomaterials.
水凝胶是交联的三维大分子网络，其结构中含有大量水分。藻酸盐水凝胶最重要的特性之一，也是其具有广泛用途的原因，是其对分子的可控摄取、释放和保留能力。反过来，这种能力归因于大分子网络与扩散或保留分子（例如离子）之间的特定相互作用。在本研究中，使用醋酸纤维素CAE电泳鉴定了活性敷料Medisorb A中所含的水溶性海藻酸钠。还证明了海藻酸AA（用作参考物质）和活性藻酸盐敷料Medisorb A的水解产物中存在古洛糖醛酸（G）和甘露糖醛酸（M）残基。使用相同技术观察到了文献中先前描述的“蛋盒”结构，并尝试对其进行解释。发现醋酸纤维素电泳是检查藻酸盐基生物材料的一种有用方法。
