Segal H C, Hunt B J, Gilding K
Research Haematology Group, Harefield Hospital, Middlesex, UK.
J Biomater Appl. 1998 Jan;12(3):249-57. doi: 10.1177/088532829801200305.
Alginates are used as haemostats in wound dressings. They act as calcium ion (Ca) donors as they contain mannuronic (M) or guluronic (G) groups with a high Ca content. This study compared the effects of calcium and zinc containing alginates and non-alginate dressings on blood coagulation and platelet activation to determine which was the best haemostat. We showed that alginate materials activated coagulation more than non-alginate materials. The extent of coagulation activation was affected differently by the alginate M or G group composition. It was demonstrated that alginates containing zinc ions had the greatest potentiating effect on prothrombotic coagulation and platelet activation.
藻酸盐在伤口敷料中用作止血剂。它们作为钙离子（Ca）供体，因为它们含有高钙含量的甘露糖醛酸（M）或古洛糖醛酸（G）基团。本研究比较了含钙和锌的藻酸盐敷料与非藻酸盐敷料对血液凝固和血小板活化的影响，以确定哪种是最佳止血剂。我们发现藻酸盐材料比非藻酸盐材料更能激活凝血。藻酸盐M或G基团组成对凝血激活程度的影响不同。结果表明，含锌离子的藻酸盐对血栓前凝血和血小板活化具有最大的增强作用。
