School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UK.
J Am Chem Soc. 2010 Feb 17;132(6):1736-7. doi: 10.1021/ja907466y.
Binding of highly branched poly(N-isopropylacrylamide) with vancomycin end groups to Staphylococcus aureus induced a coil-to-globule phase transition. The polymers aggregated this gram-positive bacteria (but not gram-negative bacteria) over a wide range of temperatures, but cooling to 24-26 degrees C progressed the polymer-bound bacteria through a globule-to-coil phase transition, after which the bacteria were released.
高度支化的聚（N-异丙基丙烯酰胺）与万古霉素末端基团与金黄色葡萄球菌的结合诱导了从线圈到球的相转变。这些聚合物在很宽的温度范围内聚集这种革兰氏阳性细菌（但不聚集革兰氏阴性细菌），但冷却到 24-26 摄氏度使聚合物结合的细菌经历了从球到线圈的相转变，之后细菌被释放。
