Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.
Int Rev Immunol. 2010;29(1):77-109. doi: 10.3109/08830180903349651.
Alternative splicing is a fine-tuned process known for generating multiple functional variants from individual genes leading to protein diversity. The immune system utilizes pre-mRNA splicing to expand its gene function. Numerous immunologically relevant genes have been found to undergo alternative splicing, thus revealing a new source of complexity in the immune gene network. This review attempts to summarize the general features of alternative splicing and its role in the immune system along with a special focus on the available reports of alternative splicing in cytokines, mainly interleukins and their receptors and their regulatory significance.
选择性剪接是一种微调的过程，可从单个基因中产生多种功能变体，从而导致蛋白质多样性。免疫系统利用前体 mRNA 剪接来扩展其基因功能。许多与免疫相关的基因已被发现发生选择性剪接，从而揭示了免疫基因网络中的一个新的复杂性来源。这篇综述试图总结选择性剪接的一般特征及其在免疫系统中的作用，特别关注细胞因子（主要是白细胞介素及其受体）中选择性剪接的现有报道及其调节意义。
