孕妇急性感染性腹泻与其后代先天性异常之间的可能关联——一项基于人群的病例对照研究。
A possible association between acute infectious diarrhoea in pregnant women and congenital abnormalities in their offspring--a population-based case-control study.
作者信息
Acs Nándor, Bánhidy Ferenc, Puhó Erzsébet H, Czeizel Andrew E
机构信息
Second Department of Obstetrics and Gynaecology, Semmelweis University, School of Medicine, Budapest, Hungary.
出版信息
Scand J Infect Dis. 2010 May;42(5):359-67. doi: 10.3109/00365540903499415.
The possible association between Salmonella gastroenteritis (SGE) and infectious diarrhoea in pregnancy (IDP) and structural birth defects, i.e. congenital abnormalities (CA) in the offspring, has not been studied. The dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996 was evaluated. There were 15 (0.07%) and 82 (0.36%) out of 22,843 cases and 23 (0.06%) and 70 (0.18%) out of 38,151 (0.34%) controls with mothers who had medically recorded SGE and IDP, respectively. There was no association of SGE and a higher risk of CA. However, a higher risk of cleft lip +/- palate, congenital limb deficiencies, multiple CAs and cardiovascular CAs was found in the offspring of mothers with IDP. A possible explanation for the association of IDP with higher risk for some specific CAs may be the high fever in IDP.
沙门氏菌肠胃炎（SGE）与妊娠期感染性腹泻（IDP）以及子代结构出生缺陷即先天性异常（CA）之间可能存在的关联尚未得到研究。对1980 - 1996年匈牙利先天性异常病例对照监测数据集进行了评估。在22,843例病例中，分别有15例（0.07%）和82例（0.36%）的母亲有医学记录的SGE和IDP；在38,151例对照中，分别有23例（0.06%）和70例（0.18%）的母亲有医学记录的SGE和IDP。SGE与CA风险升高之间无关联。然而，在患有IDP的母亲的子代中，发现唇裂±腭裂、先天性肢体缺陷、多发CA和心血管CA的风险更高。IDP与某些特定CA风险升高之间存在关联的一个可能解释可能是IDP中的高热。
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