Bánhidy Ferenc, Acs Nándor, Puhó Erzsébet H, Czeizel Andrew E
Second Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
Birth Defects Res A Clin Mol Teratol. 2010 Jun;88(6):466-73. doi: 10.1002/bdra.20664.
The aim of the study was to check the association of maternal periodontal infectious disease (MPID) during pregnancy and the possible risk for birth outcomes, mainly structural birth defects: congenital abnormalities (CAs) in their children.
The population-based data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996, was evaluated. The occurrence of medically recorded MPID in the prenatal maternity logbook was compared in 22,843 cases with different CAs and 38,151 matched controls without defects.
Twenty-one case mothers who had offspring with a CA (case group) and 17 pregnant women who delivered newborn infants without a CA (control group) had an MPID. However, of 21 cases, 6 had isolated cleft lip +/- palate (OR with 95% CI: 10.7, 4.2-27.3), and 2 were affected with isolated cleft palate (7.9, 1.8-34.2). Of these 8 cases, 6 had mothers with the exposure of MPID in the critical period of these orofacial clefts, 7 mothers were visited at home, and 6 were smokers during pregnancy.
The unexpected findings of the study showed a strong association of MPID during pregnancy with a higher risk of isolated orofacial clefts in their children.
本研究旨在探讨孕期母亲牙周感染性疾病（MPID）与出生结局的可能风险之间的关联，主要是结构出生缺陷：其子女的先天性异常（CAs）。
对匈牙利先天性异常病例对照监测系统1980 - 1996年基于人群的数据集进行评估。比较了22843例患有不同先天性异常的病例和38151例无缺陷的匹配对照在产前产妇日志中记录的MPID发生情况。
21例有先天性异常后代的病例母亲（病例组）和17例分娩无先天性异常新生儿的孕妇（对照组）患有MPID。然而，在21例病例中，6例患有单纯唇裂±腭裂（比值比及95%置信区间：10.7，4.2 - 27.3），2例患有单纯腭裂（7.9，1.8 - 34.2）。在这8例病例中，6例母亲在这些口面部裂隙的关键时期暴露于MPID，7例母亲接受了家访，6例在孕期吸烟。
该研究的意外发现表明孕期MPID与子女患单纯口面部裂隙的较高风险之间存在密切关联。
