Saunders Lee L, Selassie Anbesaw W, Hill Elizabeth G, Nicholas Joyce S, Horner Michael David, Corrigan John D, Lackland Daniel T
Department of Health Sciences and Research, Medical University of South Carolina, Charleston, 29425, USA.
Brain Inj. 2009 Oct;23(11):866-72. doi: 10.1080/02699050903283213.
The objective was to estimate and compare the hazards of repetitive traumatic brain injury (RTBI) events as a function of the index TBI severity, in a cohort of TBI hospital discharges include in the South Carolina Traumatic Brain Injury Follow-up Registry.
Retrospective cohort.
There were 4357 persons with TBI who were followed from the index hospital discharge through 31 December 2005 for RTBI events through the statewide hospital discharge (HD) and emergency department (ED) records. Prentice, Williams, Peterson total time/conditional probability model (PWP-CP) for recurrent events survival analysis was used to assess RTBI as a function of index TBI severity.
Index TBI severity approached significance in its relationship with RTBI, with persons with a severe index TBI experiencing events at a higher rate than those with a mild/moderate index TBI. Among the other covariates evaluated, epilepsy/seizure disorder, race, gender, payer status, cause of injury and having a prior history of TBI were associated with RTBI.
While TBI severity approached significance with RTBI, other variables, such as epilepsy/seizure disorder, seem to have a more significant relationship with RTBI.
目标是在南卡罗来纳州创伤性脑损伤随访登记处纳入的创伤性脑损伤（TBI）出院队列中，估计并比较作为索引TBI严重程度函数的重复性创伤性脑损伤（RTBI）事件的风险。
回顾性队列研究。
有4357名TBI患者从索引医院出院后，通过全州范围的医院出院（HD）和急诊科（ED）记录，随访至2005年12月31日的RTBI事件。使用用于复发事件生存分析的Prentice、Williams、Peterson总时间/条件概率模型（PWP-CP）来评估RTBI作为索引TBI严重程度的函数。
索引TBI严重程度与其与RTBI的关系接近显著，严重索引TBI患者发生事件的发生率高于轻度/中度索引TBI患者。在评估的其他协变量中，癫痫/癫痫发作障碍、种族、性别、付款人状态、损伤原因和有TBI既往史与RTBI相关。
虽然TBI严重程度与RTBI接近显著，但其他变量，如癫痫/癫痫发作障碍，似乎与RTBI有更显著的关系。
