Center for Structural and Functional Materials, University of Louisiana at Lafayette, Lafayette, LA 70504-4130, USA.
Acta Biomater. 2010 Jul;6(7):2732-9. doi: 10.1016/j.actbio.2010.01.025. Epub 2010 Jan 25.
The objective of the study is to describe a new approach of combining quantum dots technology with anti-cancer drug therapy. In this regard, we communicate the preliminary research on the synthesis of blue-light emitting ZnO quantum dots (QDs) combined with biodegradable chitosan (N-acetylglucosamine) for tumor-targeted drug delivery. The results presented here indicate that the proposed new generation of QDs loaded with anti-cancer agents and encapsulated with biocompatible polymer represent a potential platform to deliver tumor-targeted drugs and document the delivery process, if desired. Non-toxic water-dispersed ZnO QDs with long-term fluorescence stability were synthesized by a chemical hydrolysis method, encapsulated with chitosan and loaded with anti-cancer drug. Chitosan enhanced the stability of the QDs because of the hydrophilicity and cationic charge of chitosan. The study points toward the application of water-dispersed ZnO QDs with long-term fluorescence stability for design of new drug release carrier.
本研究旨在描述一种将量子点技术与抗癌药物治疗相结合的新方法。在这方面，我们交流了关于合成与可生物降解壳聚糖（N-乙酰葡萄糖胺）相结合的发蓝光的 ZnO 量子点（QD）用于肿瘤靶向药物递送的初步研究。这里呈现的结果表明，所提出的载有抗癌药物并封装在生物相容性聚合物中的新一代 QD 代表了一种潜在的平台，可用于递送肿瘤靶向药物并记录所需的递送过程。通过化学水解法合成了具有长期荧光稳定性的无毒水散 ZnO QD，并与壳聚糖封装并加载抗癌药物。由于壳聚糖的亲水性和阳离子电荷，壳聚糖增强了 QD 的稳定性。该研究指向了具有长期荧光稳定性的水散 ZnO QD 在设计新的药物释放载体中的应用。
