Duţu S, Jienescu Z, Popescu D, Iliescu A
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1977 Jul-Sep;26(3):165-72.
Results obtained during an epidemiological investigation on chronic cough and obstructive ventilatory dysfunction in subjects without bronchopulmonary affections of known etiopathogeny, carried out in a rural environment with minimal air pollution on 282 men aged between 40 and 69 years, indicate the following: --there was a lower prevalence of chronic cough in the rural environment as compared with the urban one (12.8:21.0). The percentage of heavy smokers being approximately similar in both environments, the difference could be explained by the variable intensity of air pollution, the impact of which was exerted on the large airways (hypertrophy of the serous-mucous glands resulting in hypercrinia with dyscrinia); --similar prevalence in the two environments of the obstructive ventilatory dysfunction (11,0:8,7) suggests that this abnormality, an expression of the narrowing of the small airways, could be due to other pathogenic factors. Functional pulmonary tests with sensitivity higher than the ratio between FEV 1.0 and VC (as, for instance VEmx 50% VC) could provide higher percentages of obstructive disturbances both among chronic coughing and non-coughing subjects, revealing the latent form of the obstruction, as opposed to the manifest one as evidenced by a decrease of the FEV 1.0/VC ratio.
在空气污染极小的农村地区，对282名年龄在40至69岁之间、无已知病因的支气管肺部疾病的男性进行了一项关于慢性咳嗽和阻塞性通气功能障碍的流行病学调查，结果如下：——与城市环境相比，农村环境中慢性咳嗽的患病率较低（12.8:21.0）。两个环境中重度吸烟者的百分比大致相似，这种差异可以用空气污染强度的变化来解释，空气污染对大气道产生影响（浆液性黏液腺肥大导致分泌亢进伴分泌失调）；——两个环境中阻塞性通气功能障碍的患病率相似（11.0:8.7），这表明这种小气道狭窄的异常可能归因于其他致病因素。与FEV 1.0与VC比值相比，具有更高敏感性的肺功能测试（例如VEmx 50% VC）在慢性咳嗽和非咳嗽受试者中均可发现更高比例的阻塞性障碍，揭示出阻塞的潜在形式，而不是像FEV 1.0/VC比值降低所证明的明显形式。
