Child and Adolescent Public Health Epidemiology Group, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Int J Obes (Lond). 2010 Apr;34(4):726-32. doi: 10.1038/ijo.2009.298. Epub 2010 Jan 26.
The aim of this study was to investigate associations between underweight, overweight and obesity in young adult men and risk of disability pension (DP) due to psychiatric disorders.
In this nationwide study of 1 110 139 Swedish men (mean age 18.3+/-0.5 years), weight, height and muscular strength were measured at mandatory military conscription testing (1969-1994). Information on DP (1971-2006), residential area, parental socioeconomic position and education and preexisting psychiatric disorders was obtained by record linkage of national registers.
During 26 million person-years of follow-up, 19 684 men received DP due to psychiatric disorders. After adjustment, hazard ratios (HRs) due to any psychiatric disorder were 1.20 (95% CI: 1.15-1.26) for underweight, 1.14 (95% CI: 1.08-1.21) for overweight and 1.43 (95% CI: 1.28-1.60) for obesity compared to normal weight. For affective disorders, HRs were elevated for underweight (1.24, 95% CI: 1.16-1.32), overweight (1.19, 95% CI: 1.10-1.28) and obesity (1.55, 95% CI: 1.33-1.81), whereas for substance abuse increased risks were seen only for underweight (1.41, 95% CI: 1.23-1.61) and obesity (1.50, 95% CI: 1.07-2.12). For nonaffective disorders (including schizophrenia) overweight (HR=0.87, 95% CI: 0.76-1.00) and obesity (HR=0.79, 95% CI: 0.57-1.10) seemed to be protective, although not statistically significant. HRs for personality disorders were increased for underweight (1.18, 95% CI: 1.04-1.34), overweight (1.16, 95% CI: 1.00-1.30) and obesity (1.40, 95% CI: 1.03-1.90).
Underweight and overweight were associated with small risk increases, whereas higher risks for DP were generally found for obesity.
本研究旨在探讨年轻男性体重不足、超重和肥胖与精神障碍相关残疾抚恤金（DP）风险之间的关联。
在这项针对 1110139 名瑞典男性（平均年龄 18.3±0.5 岁）的全国性研究中，在强制性兵役体检（1969-1994 年）时测量体重、身高和肌肉力量。通过国家登记册的记录链接获得 DP（1971-2006 年）、居住地区、父母社会经济地位和教育以及先前存在的精神障碍信息。
在 2600 万人年的随访期间，有 19684 名男性因精神障碍而获得 DP。调整后，任何精神障碍的风险比（HR）分别为体重不足 1.20（95%CI：1.15-1.26）、超重 1.14（95%CI：1.08-1.21）和肥胖 1.43（95%CI：1.28-1.60）。对于情感障碍，体重不足（1.24，95%CI：1.16-1.32）、超重（1.19，95%CI：1.10-1.28）和肥胖（1.55，95%CI：1.33-1.81）的 HR 升高，而物质滥用的风险增加仅见于体重不足（1.41，95%CI：1.23-1.61）和肥胖（1.50，95%CI：1.07-2.12）。对于非情感障碍（包括精神分裂症），超重（HR=0.87，95%CI：0.76-1.00）和肥胖（HR=0.79，95%CI：0.57-1.10）似乎具有保护作用，但无统计学意义。人格障碍的 HR 分别为体重不足（1.18，95%CI：1.04-1.34）、超重（1.16，95%CI：1.00-1.30）和肥胖（1.40，95%CI：1.03-1.90）。
体重不足和超重与风险略有增加有关，而肥胖与 DP 风险较高普遍相关。
