Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA.
Immunol Cell Biol. 2010 Mar-Apr;88(3):269-74. doi: 10.1038/icb.2009.105. Epub 2010 Jan 26.
Substantial evidence has been accumulated to indicate that gammadelta T cells take part in type 2 immune responses. It is not yet clear, however, in what capacity. Apparently, gammadelta T cells themselves can not only take the function of follicular T helper (T(H)) cells in certain responses, but also can support responses that are dependent on classical help provided by alphabeta T cells. Furthermore, the gammadelta T cells engage as regulators of T(H2) immunity. Here, we consider two mouse models that depend on type 2 immunity, non-specific airway hyperresponsiveness to methacholine after allergen inhalation challenge and the primary IgE response induced by alum-aided immunization, and examine the function of gammadelta T cells. In either case, gammadelta T cells regulate type 2 immunity through balanced enhancing and inhibitory influences. However, after airway allergen exposure, suppressive gammadelta T cells become dominant. The underlying mechanisms are discussed.
大量证据表明，γδ T 细胞参与 2 型免疫反应。然而，其具体作用机制尚不清楚。显然，γδ T 细胞本身不仅可以在某些反应中发挥滤泡辅助 T 细胞（T(H))的功能，还可以支持依赖经典辅助的反应由αβ T 细胞提供。此外，γδ T 细胞作为 T(H2)免疫的调节剂。在这里，我们考虑了两种依赖于 2 型免疫的小鼠模型，即吸入变应原后非特异性气道对乙酰甲胆碱的高反应性和 alum 辅助免疫诱导的原发性 IgE 反应，并研究了 γδ T 细胞的功能。在这两种情况下，γδ T 细胞通过平衡增强和抑制的影响来调节 2 型免疫。然而，在气道过敏原暴露后，抑制性 γδ T 细胞占主导地位。讨论了潜在的机制。
