过氧化物酶体增殖物激活受体（PPARs）：能量代谢和代谢性疾病中的多种调节因子。
PPARs: diverse regulators in energy metabolism and metabolic diseases.
机构信息
Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
出版信息
Cell Res. 2010 Feb;20(2):124-37. doi: 10.1038/cr.2010.13. Epub 2010 Jan 26.
Abstract
The nuclear receptor PPARs are fundamentally important for energy homeostasis. Through their distinct yet overlapping functions and tissue distribution, the PPARs regulate many aspects of energy metabolism at the transcriptional level. Functional impairment or dysregulation of these receptors leads to a variety of metabolic diseases, while their ligands offer many metabolic benefits. Studies of these receptors have advanced our knowledge of the transcriptional basis of energy metabolism and helped us understand the pathogenic mechanisms of metabolic syndrome.
摘要
核受体 PPARs 对能量稳态至关重要。通过其独特但又重叠的功能和组织分布，PPARs 在转录水平上调节能量代谢的许多方面。这些受体的功能障碍或失调会导致多种代谢疾病，而它们的配体则提供了许多代谢益处。对这些受体的研究提高了我们对能量代谢转录基础的认识，并帮助我们理解代谢综合征的发病机制。
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