重症肌无力免疫发病机制的研究进展。
Research advancement in immunopathogenesis of myasthenia gravis.
机构信息
The Second Xiangya Hospital of Central South University, Changsha 410011, China.
出版信息
Neurosci Bull. 2010 Feb;26(1):85-9. doi: 10.1007/s12264-010-0604-1.
Abstract
Myasthenia gravis (MG) is an autoimmune neuromuscular junction disease mediated by antibodies against the acetylcholine receptor (AChR). The etiology and immunopathogenesis of MG remain unclear. Recent research has shown the involvement of autoantibodies, lymphocytes, cytokines and chemokines, in the pathogenesis of MG. Systematic factors are also demonstrated, such as inheritance and endocrine. This review indicates the research development in immunopathogenesis of MG.
摘要
重症肌无力（MG）是一种由乙酰胆碱受体（AChR）抗体介导的自身免疫性神经肌肉接头疾病。MG 的病因和免疫发病机制仍不清楚。最近的研究表明，自身抗体、淋巴细胞、细胞因子和趋化因子参与了 MG 的发病机制。系统性因素也有显示，如遗传和内分泌。本文综述了 MG 免疫发病机制的研究进展。
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