重症肌无力中抗二氢吡啶受体自身抗体

Autoantibody to dihydropyridine receptor in myasthenia gravis.

作者信息

Maruta Takahiro, Yoshikawa Hiroaki, Fukasawa Shuichi, Umeshita Sho, Inaoka Yoshihiro, Edahiro Shigeki, Kado Hirotsugu, Motozaki Yuko, Iwasa Kazuo, Yamada Masahito

机构信息

Health Service Center, Kanazawa University, Kanazawa, Japan.

出版信息

J Neuroimmunol. 2009 Mar 31;208(1-2):125-9. doi: 10.1016/j.jneuroim.2009.01.001. Epub 2009 Feb 1.

DOI:10.1016/j.jneuroim.2009.01.001

PMID:19187971

Abstract

To investigate autoantibodies related to excitation-contraction (E-C) coupling in patients with myasthenia gravis (MG), we developed a novel method to detect autoantibodies against dihydropyridine receptor (DHPR). Using this method, we detected DHPR antibody in 37% (11 out of 30) of MG patients with thymoma. Antibodies were not detected in normal nor disease controls. The titer of DHPR antibodies showed no significant correlation with autoantibodies to acetylcholine nor ryanodine receptors. The DHPR antibody is another marker for thymoma in MG, and it might have some role in clinical symptoms related to E-C coupling.

摘要

为了研究重症肌无力（MG）患者中与兴奋-收缩（E-C）偶联相关的自身抗体，我们开发了一种检测抗二氢吡啶受体（DHPR）自身抗体的新方法。使用该方法，我们在30例胸腺瘤型MG患者中的37%（11例）检测到了DHPR抗体。在正常人和疾病对照中均未检测到抗体。DHPR抗体的滴度与抗乙酰胆碱或雷诺丁受体的自身抗体无显著相关性。DHPR抗体是MG中胸腺瘤的另一个标志物，它可能在与E-C偶联相关的临床症状中起一定作用。